Amiloride Inhalation Therapy in Cystic Fibrosis: Influence on Ion Content, Hydration, and Rheology of Sputum
| Autor: | Richard C Boucher, Oscar Ramirez, Malcolm King, Michael R Knowles, N. Church, J. G. Zayas, Robert P. Tomkiewicz, Ernst M. App |
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| Rok vydání: | 1993 |
| Předmět: |
Adult
Pulmonary and Respiratory Medicine medicine.medical_specialty Time Factors Adolescent Cystic Fibrosis medicine.medical_treatment Sodium chemistry.chemical_element Cystic fibrosis Amiloride Electrolytes Double-Blind Method Internal medicine Administration Inhalation medicine Humans Saline Inhalation business.industry Sputum Water medicine.disease Mucus Endocrinology chemistry Diuretic medicine.symptom Rheology business medicine.drug |
| Zdroj: | American Review of Respiratory Disease. 148:1002-1007 |
| ISSN: | 0003-0805 |
| DOI: | 10.1164/ajrccm/148.4_pt_1.1002 |
| Popis: | Amiloride inhalation as treatment for cystic fibrosis (CF) lung disease has been shown in independent studies to increase mucus clearance by ciliary and/or cough action and to retard the decline in lung function. It is hypothesized that amiloride therapy decreases the excess sodium and water absorption that is a characteristic of CF airway epithelium and that it leads to an improvement in the rheologic properties of mucus favoring airway mucus clearance. The aim of this study was to investigate whether amiloride treatment (5 x 10(-3) M amiloride in one-third normal saline four times a day) would change sputum electrolyte composition in patients with CF after 25 wk of therapy as compared with placebo (one-third normal saline), and whether appropriate changes in sputum water content and rheologic properties would accompany any changes in electrolyte composition. Sputum samples were obtained from six patients with CF undergoing amiloride therapy, using the dental cotton protection technique to avoid salivary contamination. The samples were stored at -80 degrees C until analyzed. For electrolyte analyses an aliquot of the sputum (minimum, 30 mg) was analyzed with ion-selective electrodes for sodium and potassium, and a chloride meter was used to measure chloride content. Chronic (25-wk) amiloride therapy increased significantly the sputum sodium (94.8 +/- 16.4 to 121.4 +/- 15.4 mmol/L, p = 0.001) and chloride (64.4 +/- 11.8 to 77.2 +/- 8.0 mmol/L, p = 0.10) content when compared with 25 wk of saline treatment.(ABSTRACT TRUNCATED AT 250 WORDS) |
| Databáze: | OpenAIRE |
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