Incidence, Clinical Characteristics, and Natural History of Pediatric IBD in Wisconsin
| Autor: | Tonya Adamiak, Pippa Simpson, Subramaniam Kugathasan, Justin Nebel, Michael Yaffee, Christopher W. Brown, Dorota Walkiewicz-Jedrzejczak, Richard J. Noel, Janice Heikenen, Jeanne Tung, William A. Faubion, Marcy Wiedkamp, Khalid Khan, Roger Park, Michael D. Kappelman, Melodee Nugent, Maria T. Rivera-Bennett, Daryl L. Fish, Michael C. Stephens |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Pediatrics Adolescent Population Disease Article Wisconsin Crohn Disease Epidemiology Humans Immunology and Allergy Medicine Prospective Studies Child education Retrospective Studies education.field_of_study business.industry Incidence Public health Incidence (epidemiology) Gastroenterology Prognosis digestive system diseases Natural history Cohort Etiology Colitis Ulcerative Female business Follow-Up Studies |
| Zdroj: | Inflammatory Bowel Diseases. 19:1218-1223 |
| ISSN: | 1078-0998 |
| Popis: | Crohn’s disease (CD) and ulcerative colitis (UC), collectively known as inflammatory bowel diseases (IBD), are life-long chronic inflammatory disorders of the gastrointestinal tract. It is estimated that 15% to 20% of all cases of IBD are diagnosed in the childhood and adolescent period. This period is a time of physical, emotional, and social maturation, and onset of this chronic disorder in childhood can seriously jeopardize health, growth, and education. The burden associated with this disease extends beyond that of simply physical symptoms. An increasing number of these children are being treated with immunosuppressive1 and biological2 medications. Although these medications can improve the short-term outcome and quality of life of children with IBD, they have been associated with opportunistic infections,3 malignancy,4–6 and lymphoproliferative disorders7,8 among IBD populations. Descriptive epidemiologic studies are recommended to promote the development of new etiological hypotheses and to better define the public health burden of childhood-onset IBD. A number of observational reports from Europe suggest that the incidence of pediatric IBD is increasing from 7 per 100,000 in the 1990s and 2000s.9–13 Because the majority of the North American population are of European origin, the speculation is that the incidence and prevalence of IBD in North America are equal to or even higher than that reported in Europe. Benchimol et al14 recently reported an increase in the incidence of IBD in Ontario, Canada, from 9.5 in 1994 to 11.4 in 2005. Epidemiological data of pediatric IBD in the United States are more limited. In a Northern California health plan, the annual incidence of CD per 100,000 increased from 2.2 to 4.3 from 1996 to 2006. The incidence of UC increased from 1.8 to 4.9 over the same period.15 To our knowledge, only limited epidemiological data from other regions of the United States are reported.16 Therefore, additional population-based studies are needed to accurately estimate the burden of IBD among children in North America. To impart a greater understanding of the epidemiology of IBD in a population-based model among children in North America, we aimed to determine the incidence and time trends of childhood IBD in Wisconsin and describe the clinical course and treatments in this cohort. We developed a system of capturing all possible cases of IBD presenting before the age of 18, occurring within a defined time period (the 8-year period between year 2000 and 2007 inclusive), and within the defined geographic locale of Wisconsin, an upper midwestern state in the United States (54,310 square miles, 5.5 million population). We then tested the hypothesis that the incidence of pediatric IBD has increased over this 8-year time period. |
| Databáze: | OpenAIRE |
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