Increased admission and fasting glucose are associated with unfavorable short-term outcome after intra-arterial treatment of ischemic stroke in the MR CLEAN pretrial cohort
| Autor: | H. M. den Hertog, Elizabeth Osei, Adrienne A.M. Zandbergen, Debbie Beumer, Jelis Boiten, Yvo B.W.E.M. Roos, Puck S. S. Fransen, Diederik W.J. Dippel, Peter J. Koudstaal, Olvert A. Berkhemer, Wouter J. Schonewille, R. J. van Oostenbrugge |
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| Přispěvatelé: | Neurology, MUMC+: MA AIOS Neurologie (9), MUMC+: MA Neurologie (3), Klinische Neurowetenschappen, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, RS: CARIM - R3.03 - Cerebral small vessel disease, Radiology and Nuclear Medicine, ANS - Neurovascular Disorders |
| Rok vydání: | 2016 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty IFG Severity of Illness Index Brain Ischemia Fasting glucose 03 medical and health sciences 0302 clinical medicine Patient Admission Modified Rankin Scale Internal medicine medicine Intra arterial Odds Ratio Humans Thrombolytic Therapy 030212 general & internal medicine Registries Acute ischemic stroke Intra-arterial treatment Thrombectomy business.industry Endovascular Procedures Odds ratio Fasting Middle Aged Impaired fasting glucose medicine.disease Prognosis Surgery Stroke Logistic Models Treatment Outcome Glucose Neurology Hyperglycemia Ischemic stroke Cohort Cardiology Female Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Journal of the Neurological Sciences, 371, 1-5. Elsevier Journal of the Neurological Sciences, 371, 1-5. Elsevier Science Journal of the neurological sciences, 371, 1-5. Elsevier |
| ISSN: | 0022-510X |
| Popis: | Background Limited data are available on the impact of fasting glucose on outcome after intra-arterial treatment (IAT). We studied whether hyperglycemia on admission and impaired fasting glucose (IFG) are associated with unfavorable outcome after IAT in acute ischemic stroke. Methods Patients were derived from the pretrial registry of the MR CLEAN-trial. Hyperglycemia on admission was defined as glucose > 7.8 mmol/L, IFG as fasting glucose > 5.5 mmol/L in the first week of admission. Primary effect measure was the adjusted common odds ratio (acOR) for a shift in the direction of worse outcome on the modified Rankin Scale at discharge, estimated with ordinal logistic regression, adjusted for common prognostic factors. Results Of the 335 patients in which glucose on admission was available, 86 (26%) were hyperglycemic, 148 of the 240 patients with available fasting glucose levels (62%) had IFG. Median admission glucose was 6.8 mmol/L (IQR 6–8). Increased admission glucose (acOR 1.2, 95%CI 1.1–1.3), hyperglycemia on admission (acOR 2.6, 95%CI 1.5–4.6) and IFG (acOR 2.8, 95%CI 1.4–5.6) were associated with worse functional outcome at discharge. Conclusion Increased glucose on admission and IFG in the first week after stroke onset are associated with unfavorable short-term outcome after IAT of acute ischemic stroke. |
| Databáze: | OpenAIRE |
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