Potential Anti-Tumor Drug: Co-Crystal 5-Fluorouracil-nicotinamide
Autor: | Nan Yu, Shan Gao, Zhao-Peng Deng, Min Li, Zhu-Yan Zhang, Cong Liu, Han Siying, Chang Xue, John J. Castellot |
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Rok vydání: | 2019 |
Předmět: | |
Zdroj: | ACS Omega ACS Omega, Vol 5, Iss 26, Pp 15777-15782 (2020) |
ISSN: | 2470-1343 |
Popis: | 5-Fluorouracil-nicotinamide (5-FU-NCM), a co-crystal with a 2D layer structure formed by hydrogen bonds, was synthesized by solvent evaporation and liquid phase-assisted grinding at room temperature. Compared to 5-FU alone, the results of solubility, oil-water partition coefficient, anti-tumor effect in vivo and vitro, acute toxicity, and pharmacokinetic parameters indicate that the co-crystal is a potential anti-tumor drug. |
Databáze: | OpenAIRE |
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