Potential Anti-Tumor Drug: Co-Crystal 5-Fluorouracil-nicotinamide

Autor:	Nan Yu, Shan Gao, Zhao-Peng Deng, Min Li, Zhu-Yan Zhang, Cong Liu, Han Siying, Chang Xue, John J. Castellot
Rok vydání:	2019
Předmět:	Nicotinamide Hydrogen bond Chemistry General Chemical Engineering Evaporation General Chemistry Acute toxicity Article Partition coefficient chemistry.chemical_compound Pharmacokinetics In vivo Solubility QD1-999 Nuclear chemistry
Zdroj:	ACS Omega ACS Omega, Vol 5, Iss 26, Pp 15777-15782 (2020)
ISSN:	2470-1343
Popis:	5-Fluorouracil-nicotinamide (5-FU-NCM), a co-crystal with a 2D layer structure formed by hydrogen bonds, was synthesized by solvent evaporation and liquid phase-assisted grinding at room temperature. Compared to 5-FU alone, the results of solubility, oil-water partition coefficient, anti-tumor effect in vivo and vitro, acute toxicity, and pharmacokinetic parameters indicate that the co-crystal is a potential anti-tumor drug.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a654afe915c83ce6a9c21a792a12f63c https://pubmed.ncbi.nlm.nih.gov/32656396 Zobrazit plný text záznamu