Update: Innate Lymphoid Cells in Inflammatory Bowel Disease
Autor: | Li Tian, Xiangrui Meng, Weiwei Luo, Mengwei Xiao, Bei Tan, Zhaohua Shen, Xing Wu, Xiaoyan Wang, Shuai Wu |
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Rok vydání: | 2021 |
Předmět: |
medicine.medical_specialty
Physiology Relapse rate Inflammatory bowel disease Pathogenesis 03 medical and health sciences 0302 clinical medicine Immune system T-Lymphocyte Subsets Internal medicine Drug Discovery medicine Humans Mucosal homeostasis business.industry Innate lymphoid cell Gastroenterology Hepatology Inflammatory Bowel Diseases medicine.disease Immunity Innate Gut microbiome 030220 oncology & carcinogenesis Immunology 030211 gastroenterology & hepatology business |
Zdroj: | Digestive Diseases and Sciences. 67:56-66 |
ISSN: | 1573-2568 0163-2116 |
Popis: | Inflammatory bowel disease (IBD) is a chronic and nonspecific intestinal inflammatory condition with high relapse rate. Its pathogenesis has been linked to dysbacteriosis, genetic and environmental factors. In recent years, a new type of lymphocytes, termed innate lymphoid cells, has been described and classified into three subtypes of innate lymphoid cells-group 1, group 2 and group 3. An imbalance among these subsets' interaction with gut microbiome, and other immune cells affects intestinal mucosal homeostasis. Understanding the role of innate lymphoid cells may provide ideas for developing novel and targeted approaches for treatment of IBD. |
Databáze: | OpenAIRE |
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