Immunopathology of Experimental Autoimmune Uveoretinitis in Primates
| Autor: | Qian Li, Robert B. Nussenblatt, Yujiro Fujino, Naofumi Hikita, Chi-Chao Chan, Hum Chung, Igal Gery |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty Pathology Sialic Acid Binding Ig-like Lectin 2 T-Lymphocytes CD3 Immunology Biology medicine.disease_cause Pineal Gland Autoimmune Diseases Autoimmunity Uveitis Pineal gland Antigen Antigens CD Lectins Immunopathology medicine Animals Immunology and Allergy B-Lymphocytes Macrophages Retinitis Uveitis Posterior HLA-DR Antigens medicine.disease Immunohistochemistry Macaca mulatta eye diseases Antigens Differentiation B-Lymphocyte Disease Models Animal medicine.anatomical_structure Gliosis CD4 Antigens biology.protein Female Histopathology medicine.symptom Cell Adhesion Molecules |
| Zdroj: | Autoimmunity. 13:303-309 |
| ISSN: | 1607-842X 0891-6934 |
| DOI: | 10.3109/08916939209112339 |
| Popis: | The eyes and pineal glands from 10 monkeys immunized with S-antigen were studied using routine histopathological and immunohistochemical techniques. Seven out of 10 animals developed uveitis between 19 and 33 days after the initial immunization. Histopathology of the eyes harvested 70 days after immunization showed moderate to marked uveoretinitis, subretinal fibrosis, retinal necrosis and gliosis. The pineal glands demonstrated chronic pinealitis. The infiltrating cells were both CD3 and CD19/CD22 lymphocytes with a ratio of 1.4 in the eye and 2.2 in the pineal gland. The ratio of CD4 to CD8 lymphocytes was 1.5:1. MHC Class II antigens and adhesion molecule (ICAM-1) were observed on resident cells. The influx of B lymphocytes and the formation of subretinal fibrosis differentiate the disease in the monkey from that in the rat and mouse. These findings are similar to Vogt-Koyanagi-Harada syndrome and subretinal fibrosis with uveitis syndrome in human. |
| Databáze: | OpenAIRE |
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