Colonization With Methicillin-resistant Staphylococcus aureus and Risk for Infection Among Asymptomatic Athletes: A Systematic Review and Metaanalysis
| Autor: | Tori Kinamon, Styliani Karanika, Eleftherios Mylonakis, Christos Grigoras |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Microbiology (medical)
Relative risk reduction Male Methicillin-Resistant Staphylococcus aureus medicine.medical_specialty Population medicine.disease_cause Asymptomatic Risk Assessment 03 medical and health sciences 0302 clinical medicine Intensive care Internal medicine Prevalence Medicine Humans 030212 general & internal medicine education education.field_of_study biology business.industry Athletes Incidence (epidemiology) 030229 sport sciences Staphylococcal Infections biology.organism_classification Methicillin-resistant Staphylococcus aureus Surgery Infectious Diseases Relative risk Female Staphylococcal Skin Infections medicine.symptom business |
| Zdroj: | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 63(2) |
| ISSN: | 1537-6591 |
| Popis: | Background Athletes are a vulnerable population for methicillin-resistant Staphylococcus aureus (MRSA) infection. Our aim was to determine MRSA colonization in asymptomatic athletes and estimate the risk for subsequent MRSA infection. Methods We searched the PubMed and EMBASE (through 29 October 2015) for studies on MRSA colonization among asymptomatic athletes. Results The pooled prevalence of MRSA colonization among athletes was 6% (95% confidence interval [CI], 1,13), and it was higher in the United States (8%; 95% CI, 2,17). USA300 was the most common strain detected (22%), and 62% and 36% of isolates were resistant to clindamycin and trimethoprim/sulfamethoxazole, respectively. The prevalence of MRSA colonization among collegiate athletes reached 13% (95% CI, 4,25). Sports with the highest prevalence among collegiate athletes were wrestling (22%; 95% CI, 0,85), football (8%; 95% CI, 3,15) and basketball (8%; 95% CI, 0,28). The risk for MRSA skin and soft tissue infection within 3 months after documented colonization among MRSA-colonized athletes was significantly higher than for noncolonized athletes (relative risk = 7.37, 95% CI, [2.47,21.94]). Decolonization treatment among colonized athletes decreased significantly the risk for infection (relative risk reduction = 0.33; 95% CI, .03,4.28). Conclusions The prevalence of MRSA colonization among asymptomatic athletes is comparable to that among individuals with chronic illness, it is higher among collegiate athletes and can be twice that for patients in intensive care units. Importantly, colonization is associated with a >7-fold increase in the incidence of subsequent MRSA infection. Infection control and decontamination protocols for this population need to be studied and implemented with urgency. |
| Databáze: | OpenAIRE |
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