Protective effects of zinc sulfate and l-lysine on acute ethanol toxicity in mice
| Autor: | J. H. Bidanset, Ijaz S. Jamall, Ceasar Lau-Cam, Michael Greening, Vincent de Paul Lynch, John E. Mignano |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Male
Time Factors Lysine chemistry.chemical_element Pilot Projects Zinc Pharmacology Multiple dosing complex mixtures Biochemistry Mice chemistry.chemical_compound Animals Longitudinal Studies General Environmental Science Ethanol Chemistry Acute ethanol Blood ethanol Toxic dose Drug Combinations Liver Toxicity |
| Zdroj: | Environmental Research. 19:112-120 |
| ISSN: | 0013-9351 |
| DOI: | 10.1016/0013-9351(79)90039-2 |
| Popis: | Survival rates were determined in three groups of male CF-1 mice, treated ip with single and multiple doses of zinc sulfate and/or l -lysine, each alone and in combination, followed by administration of an acute toxic dose of ethanol 1 hr post-treatment. Significant protective effects were observed in all pretreated groups. Zinc and lysine (combined)-treated groups showed a maximal protective effect. Blood ethanol determinations were also made in mice similarly pretreated with zinc sulfate (5 μg/kg) and/or l -lysine (2.5 g/kg) ip and subjected to 4.55 g/kg ethanol ip 1 hr post-treatment. Blood ethanol values were significantly lower in the lysine-treated group ( P P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|