Charged Polypeptide Vesicles with Controllable Diameter
| Autor: | Eric P. Holowka, Timothy J. Deming, Darrin J. Pochan |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Membrane Fluidity
Biocompatible Materials Biochemistry Micelle Catalysis Colloid and Surface Chemistry Polymer chemistry Amphiphile Fluorescence microscope Membrane fluidity Nanotechnology Microscopy Phase-Contrast Polylysine Micelles Liposome Nanotubes Aqueous solution Chemistry Vesicle General Chemistry Polyglutamic Acid Chemical engineering Microscopy Electron Scanning Extrusion Peptides Hydrophobic and Hydrophilic Interactions Oligopeptides |
| Zdroj: | Journal of the American Chemical Society. 127:12423-12428 |
| ISSN: | 1520-5126 0002-7863 |
| Popis: | We report the preparation and characterization of charged, amphiphilic block copolypeptides that form stable vesicles and micelles in aqueous solution. Specifically, we prepared and studied the aqueous self-assembly of a series of poly(L-lysine)-b-poly(L-leucine) block copolypeptides, KxLy, where x ranged from 20 to 80 and y ranged from 10 to 30 residues, as well as the poly(L-glutamatic acid)-b-poly(L-leucine) block copolypeptide, E60L20. Furthermore, the vesicular assemblies show dynamic properties, indicating a high degree of membrane fluidity. This characteristic provides stimuli-responsive properties to the vesicles and allows fine adjustment of vesicle size using liposome-based extrusion techniques. Vesicle extrusion also provides a straightforward means to trap solutes, making the vesicles promising biomimetic encapsulants. |
| Databáze: | OpenAIRE |
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