Post-tyrosinase Inhibition of Melanogenesis by Melatonin in Hair Follicles in Vitro
| Autor: | Ann Logan, Brian Weatherhead |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
endocrine system
medicine.medical_specialty Tyrosinase Hamster Dermatology Biology Biochemistry Melanin Melatonin Cricetinae Internal medicine medicine Animals Melanocyte-Stimulating Hormones Receptor Molecular Biology Cells Cultured Melanins Dose-Response Relationship Drug integumentary system Monophenol Monooxygenase Cell Biology Hair follicle In vitro Endocrinology medicine.anatomical_structure Depression Chemical Melanocytes Catechol Oxidase hormones hormone substitutes and hormone antagonists Hair Hormone medicine.drug |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 0022-202X |
| DOI: | 10.1111/1523-1747.ep12514608 |
| Popis: | In short-term (48 hr) culture hair follicles of the Siberian hamster retain both tyrosinase activity and the capacity to produce melanin. The addition of melatonin to such cultures at concentrations between 10 −6 M and 10 −10 M brings about a dose-related inhibition of melanogenesis but tyrosinase activity is unaffected. The use of a series of melatonin analogues and blockers suggests that the hair follicle melanocytes possess melatonin receptors, although their location remains to be determined. Melatonin also inhibits the increase in melanogenesis brought about by α -melanocyte-stimulating hormone (MSH) but again it has no effect upon the increased levels of tyrosinase which accompany this MSH response. It is suggested that melatonin inhibits melanogenesis through a mechanism which operates at some post-tyrosinase step in the melanin biosynthetic pathway. |
| Databáze: | OpenAIRE |
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