Adverse muscle composition is linked to poor functional performance and metabolic comorbidities in NAFLD

Autor: Mattias Ekstedt, Jennifer Linge, Olof Dahlqvist Leinhard
Rok vydání: 2021
Předmět:
Sarcopenia
Myosteatosis
Skeletal muscle
AMC
Type 2 diabetes
CHD
coronary heart disease
Grip strength
Liver disease
Diabetes mellitus
FFMV
fat-tissue free muscle volume
non-alcoholic steatohepatitis
Non-alcoholic steatohepatitis
PDFF
PDFF
proton density fat fraction
Immunology and Allergy
Fatty liver
coronary heart disease
Cardiovascular disease
DXA
Gastroenterology
muscle fat infiltration
Magnetic resonance imaging
NAFLD
proton density fat fraction
T2D
medicine.anatomical_structure
fat-tissue free muscle volume
FIB-4
fibrosis-4
HbA1c
Research Article
NAFLD
non-alcoholic fatty liver disease
medicine.medical_specialty
NASH
non-alcoholic steatohepatitis
dual-energy x-ray absorptiometry
FFMV
T2D
type 2 diabetes
Gastroenterology and Hepatology
MFI
muscle fat infiltration
DXA
dual-energy x-ray absorptiometry
glycated haemoglobin
MFI
virtual control group
Internal medicine
Gastroenterologi
Internal Medicine
medicine
VCG
virtual control group
FIB-4
fibrosis-4
lcsh:RC799-869
adverse muscle composition
CHD
Hepatology
business.industry
medicine.disease
Comorbidity
non-alcoholic fatty liver disease
NASH
AMC
adverse muscle composition
HbA1c
glycated haemoglobin
lcsh:Diseases of the digestive system. Gastroenterology
type 2 diabetes
VCG
business
Zdroj: JHEP Reports, Vol 3, Iss 1, Pp 100197-(2021)
JHEP Reports
ISSN: 2589-5559
DOI: 10.1016/j.jhepr.2020.100197
Popis: Background & Aims Sarcopenia and frailty are recognised as important factors in later stages of liver disease. However, their role in non-alcoholic fatty liver disease (NAFLD) is not yet fully understood. In this study we investigate the associations of MRI-measured adverse muscle composition (AMC: low muscle volume and high muscle fat) with poor function, sarcopenia, and metabolic comorbidity within NAFLD in the large UK Biobank imaging study. Methods A total of 9,545 participants were included. Liver fat, fat-tissue free muscle volume, and muscle fat infiltration were quantified using a rapid MRI protocol and automated image analysis (AMRA® Researcher). For each participant, a personalised muscle volume z-score (sex- and body size-specific) was calculated and combined with muscle fat infiltration for AMC detection. The following outcomes were investigated: functional performance (hand grip strength, walking pace, stair climbing, falls) and metabolic comorbidities (coronary heart disease, type 2 diabetes). Sarcopenia was detected by combining MRI thresholds for low muscle quantity and low hand grip strength according to the European working group definition. Results The prevalence of sarcopenia in NAFLD (1.6%) was significantly lower (p
Graphical abstract
Highlights • The role of sarcopenia and frailty in NAFLD is not yet fully understood. • Magnetic resonance imaging enables quantification of muscle composition. • Myosteatosis in combination with low muscle volume characterises an adverse muscle composition. • Adverse muscle composition is a novel NAFLD phenotype associated with poor function and metabolic comorbidity. • Sarcopenia guidelines can be strengthened by including cut-offs for muscle fat.
Databáze: OpenAIRE
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