Tumor necrosis factor production by human T-cells stimulated with bacterial superantigens
| Autor: | Youngnian Gu, Ken'ichi Imanishi, Hideo Igarashi, Katsuya Inada, Takehiko Uchiyama, Hidenobu Akatsuka |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Staphylococcus aureus
Streptococcus pyogenes T-Lymphocytes Immunology Exotoxins Enterotoxin Biology In Vitro Techniques medicine.disease_cause Microbiology Enterotoxins Bacterial Proteins Tumor necrosis factor production HLA Antigens medicine Superantigen Humans Lymphotoxin-alpha Pharmacology Superantigens Toxin Tumor Necrosis Factor-alpha Toxic shock syndrome Membrane Proteins medicine.disease Interleukin-2 Tumor necrosis factor alpha CD8 Exotoxin |
| Zdroj: | International journal of immunopharmacology. 17(10) |
| ISSN: | 0192-0561 |
| Popis: | Tumor necrosis factor (TNF) production from T-cells stimulated with superantigenic exotoxins, staphylococcal enterotoxin B and streptococcal pyrogenic exotoxin A was investigated in the presence of cells bearing distinct isotypes of HLA class II molecules. The main T-cell subset for TNF production was investigated in parallel. Similarly high levels of TNF production were induced upon stimulation with the toxins in the presence of DR+ or DQ+ cells, but only marginal levels of TNF production were induced in the presence of DP+ cells. Although both CD4+ T-cells and CD8+ T-cells produced TNF-alpha and TNF-beta in response to toxin stimulation in the presence of HLA class II+ cells, the former T-cell subset was the major source of producers of TNF-alpha and TNF-beta. |
| Databáze: | OpenAIRE |
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