Effects of diphenylhydantoin and chloroquine on monkey liver microsomal mixed‐function oxidases
| Autor: | Morris F. Cranmer, Anita J. Peoples, James E. Davis |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Male
endocrine system Adult male Biology Pharmacology Toxicology Mixed Function Oxygenases Chloroquine medicine Animals Drug Interactions Saimiri chemistry.chemical_classification Potent inducer In vitro toxicology Saimiri sciureus Haplorhini Organ Size Pollution Enzyme Mixed Function Oxidase chemistry Biochemistry Phenytoin Microsomes Liver Microsome Oxidoreductases medicine.drug |
| Zdroj: | Journal of Toxicology and Environmental Health. 2:1193-1199 |
| ISSN: | 0098-4108 |
| DOI: | 10.1080/15287397709529517 |
| Popis: | Sixteen adult male squirrel monkeys (Saimiri sciureus) were randomly divided into three treatment groups and one control group. Each treatment group received 10 mg/kg oral doses of diphenylhydantoin and/or chloroquine. Following sacrifice, in vitro assays for activity of liver microsomal mixed-function oxidases were run. The assays confirmed diphenylhydantoin as a potent inducer of mixed-function oxidases. Chloroquine administration had little affect on the enzymes assayed and did not inhibit the diphenylhydantoin induction. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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