Sarcomatoid carcinoma of the upper aerodigestive tract: An immunohistochemical analysis demonstrating latent Epstein-Barr virus in a subset of eight cases
| Autor: | Ayca Tan, Demet Etit, Suheyla Cumurcu, Deniz Altinel, Umit Bayol |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Microbiology (medical) Epstein-Barr Virus Infections Herpesvirus 4 Human Pathology medicine.medical_specialty Aerodigestive tract lcsh:QR1-502 sarcomatoid carcinoma Vimentin Digestive System Neoplasms medicine.disease_cause lcsh:Microbiology Pathology and Forensic Medicine Viral Matrix Proteins Viral Proteins hemic and lymphatic diseases medicine Carcinoma lcsh:Pathology Humans Sarcomatoid carcinoma Epstein–Barr virus infection Aged biology squamous cell General Medicine Middle Aged medicine.disease Epstein–Barr virus Respiratory Tract Neoplasms Epstein-Barr virus Epstein-Barr Virus Nuclear Antigens Aerodigestive Tract DNA Viral immunohistochemistry biology.protein Immunohistochemistry Female Carcinogenesis lcsh:RB1-214 |
| Zdroj: | Indian Journal of Pathology and Microbiology, Vol 53, Iss 4, Pp 750-756 (2010) |
| ISSN: | 0974-5130 0377-4929 |
| Popis: | Background: Sarcomatoid or spindle cell carcinomas are rare malignancies which are considered as a poorly differentiated variant of squamous cell carcinoma. Epstein-Barr virus (EBV) is associated with a wide variety of malignancies. Materials and Methods: We examined the expression of EBV latent membrane protein-1 (LMP-1) and EBV EBNA-2 as well as the immunohistochemical profile of AE-1/AE-3, vimentin, desmin, CK 5-6, smooth muscle actin (SMA), p63, S-100, p53 and CD-117 with the clinicopathological correlation of eight patients of sarcomatoid carcinoma (SC) in the upper aerodigestive tract. Results: Four cases showed EBV LMP-1 positivity (50%) and there was no EBV EBNA-2 positivity. However, the EBV LMP-1 results of our series could be considered only as a coincidental finding in the SCs of the upper aerodigestive tract. Conclusions: This finding supports the idea that further studies based on larger series might be helpful enlighting the role played by EBV in carcinogenesis of SC. |
| Databáze: | OpenAIRE |
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