Assessment of inner and outer retinal layer metrics on the Cirrus HD-OCT Platform in normal eyes
| Autor: | Jamie Reese, Peter M Kaiser, Justis P. Ehlers, Sunil K. Srivastava, Sruthi Arepalli, Neeley Dukles, Ming Hu |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Visual acuity Eye Diseases genetic structures Vision Visual Acuity lcsh:Medicine Social Sciences Retinal Pigment Epithelium Macular Degeneration chemistry.chemical_compound 0302 clinical medicine Germany Medicine and Health Sciences Psychology lcsh:Science Child Aged 80 and over Multidisciplinary medicine.diagnostic_test Retinal Degeneration Middle Aged medicine.anatomical_structure Physical Sciences Retinal Disorders Female Sensory Perception Cirrus Anatomy medicine.symptom Tomography Optical Coherence Research Article Adult medicine.medical_specialty Adolescent Ellipsoids Ocular Anatomy Geometry Retina Young Adult 03 medical and health sciences Optical coherence tomography Ocular System Ophthalmology medicine Humans Retinopathy Outer nuclear layer Aged Diabetic Retinopathy Retinal pigment epithelium business.industry Attenuation lcsh:R Retinal Detachment Biology and Life Sciences Retinal eye diseases 030104 developmental biology chemistry 030221 ophthalmology & optometry Eyes lcsh:Q sense organs business Head Mathematics Neuroscience |
| Zdroj: | PLoS ONE PLoS ONE, Vol 13, Iss 10, p e0203324 (2018) |
| ISSN: | 1932-6203 |
| Popis: | PURPOSE:Ellipsoid zone (EZ) and outer retinal integrity are strongly linked to visual prognosis, but quantitative normative data is lacking. This study evaluates the EZ, outer retina, and inner retina in eyes without macular disease across a wide age spectrum. METHODS:An IRB-approved study was performed for eyes without macular pathology undergoing Spectral Domain Optical Coherence Tomography (SD-OCT) scans on the Cirrus HD-OCT system (Carl Zeiss Meditec, Oberkochen, Germany). Scans were analyzed using a previously described automated EZ mapping tool with line-by-line manual verification. Segmentation included internal limiting membrane (ILM), outer nuclear layer/Henle fiber layer complex (ONL/HFL), EZ, and the retinal pigment epithelium (RPE). The output included metrics for the inner retina (ILM-OPL/HFL), outer retina (ONL/HFL-RPE), EZ-RPE area and volume, and en face EZ mapping. EZ-RPE attenuation on en face mapping was defined as EZ-RPE thickness < 20 um, and total attenuation was 0 um. Imaging parameters were assessed for the group and compared to age, sex, visual acuity and spherical equivalent. RESULTS:167 eyes from 167 subjects were included. Mean age was 49.7 years (range 10-84 years). The mean foveal retinal thickness was 200.58 ± 19.22 um. Mean inner retinal thickness was 21.47 ± 13.60 um. Mean outer retinal thickness was 179.11 ± 18.52 um. Mean EZ-RPE thickness was 50.58 ± 6.01um. The mean EZ-RPE volume was 1.20 ± 0.10 mm3. Mean EZ attenuation percentage per macular map area was 0.87% ± 1.13% and mean percentage total attenuation was 0.12% ± 0.14%. Total and inner retinal thickness metrics decreased with age. Mean outer retinal thickness increased with age. EZ-RPE parameters were unchanged with age. However, EZ attenuation was negatively correlated with age. CONCLUSION:This study provides important information for inner and outer retinal parameters. Future research on quantitative EZ integrity can utilize this data for comparison. |
| Databáze: | OpenAIRE |
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