Kidney-on-a-Chip Technology for Drug-Induced Nephrotoxicity Screening
| Autor: | Henriëtte L. Lanz, Paul Vulto, Martijn J. Wilmer, Chee Ping Ng, Rosalinde Masereeuw, Laura Suter-Dick |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Drug High-throughput screening media_common.quotation_subject Drug Evaluation Preclinical Bioengineering Computational biology Pharmacology Kidney Models Biological Organ-on-a-chip Nephrotoxicity 03 medical and health sciences Organ Culture Techniques In vivo Humans Medicine media_common business.industry Acute kidney injury Acute Kidney Injury Microfluidic Analytical Techniques medicine.disease Renal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11] 030104 developmental biology medicine.anatomical_structure Drug development business Biotechnology |
| Zdroj: | Trends in Biotechnology, 34, 156-70 Trends in Biotechnology, 34, 2, pp. 156-70 |
| ISSN: | 0167-7799 |
| Popis: | Contains fulltext : 170854.pdf (Publisher’s version ) (Closed access) Improved model systems to predict drug efficacy, interactions, and drug-induced kidney injury (DIKI) are crucially needed in drug development. Organ-on-a-chip technology is a suitable in vitro system because it reproduces the 3D microenvironment. A kidney-on-a-chip can mimic the structural, mechanical, transport, absorptive, and physiological properties of the human kidney. In this review we address the application of state-of-the-art microfluidic culturing techniques, with a focus on culturing kidney proximal tubules, that are promising for the detection of biomarkers that predict drug interactions and DIKI. We also discuss high-throughput screening and the challenges for in vitro to in vivo extrapolation (IVIVE) that will need to be overcome for successful implementation. |
| Databáze: | OpenAIRE |
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Full Text from ScienceDirect