Investigating Spectrum of Biological Activity of 4- and 5-Chloro-2-hydroxy-N-[2-(arylamino)-1-alkyl-2-oxoethyl]benzamides
| Autor: | Marcela Vejsova, Josef Jampilek, Matus Pesko, Jirina Stolarikova, Ales Imramovsky, Katarina Kralova, Jarmila Vinšová |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Spinacia
Stereochemistry Chemical structure in vitro antimycobacterial activity Pharmaceutical Science Microbial Sensitivity Tests Article Analytical Chemistry Mycobacterium Electron Transport lcsh:QD241-441 lcsh:Organic chemistry spinach chloroplasts Drug Discovery medicine lipophilicity salicylanilide derivates in vitro antifungal activity in vitro antibacterial activity PET inhibition structure–activity relationships Physical and Theoretical Chemistry Alkyl Chromatography High Pressure Liquid chemistry.chemical_classification biology Organic Chemistry Isoniazid Biological activity biology.organism_classification Anti-Bacterial Agents Penicillin chemistry Chemistry (miscellaneous) Lipophilicity Benzamides Molecular Medicine Spinach medicine.drug |
| Zdroj: | Molecules, Vol 16, Iss 3, Pp 2414-2430 (2011) Molecules Molecules; Volume 16; Issue 3; Pages: 2414-2430 |
| ISSN: | 1420-3049 |
| Popis: | In this study, a series of twenty-two 5-chloro-2-hydroxy-N-[2-(arylamino)-1-alkyl-2-oxoethyl]benzamides and ten 4-chloro-2-hydroxy-N-[2-(arylamino)-1-alkyl-2-oxoethyl]benzamides is described. The compounds were analyzed using RP-HPLC to determine lipophilicity. Primary in vitro screening of the synthesized compounds was performed against mycobacterial, bacterial and fungal strains. They were also evaluated for their activity related to the inhibition of photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts. The compounds showed biological activity comparable with or higher than the standards isoniazid, fluconazole, penicillin G or ciprofloxacin. For all the compounds, the relationships between the lipophilicity and the chemical structure of the studied compounds as well as their structure-activity relationships are discussed. |
| Databáze: | OpenAIRE |
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