Granulocytic Sarcomas of Small Intestine and Brain are Associated with Acute Myelomonocytic Leukaemia with Abnormal Eosinophils and Inversion of Chromosome 16
| Autor: | P. Shepherd, J. Porter, J. D. M. Richards, M. S. Hamilton |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Pathology Central nervous system Leukemia Myelomonocytic Acute Diagnosis Differential Leukocyte Count Chromosome 16 Duodenal Neoplasms Leukemic Infiltration Myeloblastoma Internal medicine Biomarkers Tumor Humans Medicine Cerebral Cortex Hematology Jejunal Neoplasms business.industry Incidence Inversion (evolutionary biology) Bone Marrow Examination Middle Aged Precursor Cell Lymphoblastic Leukemia-Lymphoma Prognosis medicine.disease Small intestine Eosinophils Bowel obstruction medicine.anatomical_structure Oncology Leukemia Myeloid Chromosome Inversion Acute myelomonocytic leukemia Immunology Female business Chromosomes Human Pair 16 Intestinal Obstruction |
| Zdroj: | Leukemia & Lymphoma. 8:409-413 |
| ISSN: | 1029-2403 1042-8194 |
| DOI: | 10.3109/10428199209051022 |
| Popis: | We report two cases of acute myelomonocytic leukaemia with abnormal eosinophils (M4Eo) in which the presenting feature was small bowel obstruction. We suggest there is a unique clinicopathological association between small intestine involvement with leukaemia and the M4Eo subtype. Central nervous system involvement by myeloblastoma occurred in one of the two cases which is a recognised feature of M4Eo and should necessitate prophylaxis with intrathecal therapy. Inversion of chromosome 16 which is a cytogenetic marker for M4Eo was demonstrable in one of the two cases. |
| Databáze: | OpenAIRE |
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