Perinatal selective serotonin reuptake inhibitor medication (SSRI) effects on social behaviors, neurodevelopment and the epigenome

Autor: Tim F. Oberlander, Christina M. Ragan, Mariah Hazlett, Daniel L.A. van den Hove, Michal Dubovicky, Mary Gemmel, Eszter Bögi, Thierry Charlier, Jodi L. Pawluski
Přispěvatelé: Department of Biological Sciences [Athens], Ohio University, Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Science [Bratislava] (SAS), Department of Psychology, Colgate University, Maastricht University [Maastricht], Julius-Maximilians-Universität Würzburg (JMU), University of British Columbia (UBC), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), JLP is funded by a Brain & Behavior Foundation NARSAD Young Investigator Grant. TDC is funded by the Region Bretagne (SAD) and Rennes Metropole. MD is funded by the VEGA project 2/0168/15 (Slovak Grant Agency)., Cadieu, Muriel, Julius-Maximilians-Universität Würzburg [Wurtzbourg, Allemagne] (JMU), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Slovak Academy of Science [Bratislava] ( SAS ), University of Würzburg, University of British Columbia ( UBC ), Institut de recherche, santé, environnement et travail ( Irset ), Université d'Angers ( UA ) -Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -École des Hautes Études en Santé Publique [EHESP] ( EHESP ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) -Université des Antilles ( UA ), RS: MHeNs - R3 - Neuroscience, Psychiatrie & Neuropsychologie
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Maternal anxiety
Maternal stress
[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
Antidepressant
ANXIETY-LIKE BEHAVIOR
Social interaction
Behavioral Neuroscience
0302 clinical medicine
Pregnancy
MOTHER-INFANT INTERACTIONS
PRENATAL ANTIDEPRESSANT EXPOSURE
SSRI
ComputingMilieux_MISCELLANEOUS
Depression
digestive
oral
and skin physiology
[SDV.BDD.EO] Life Sciences [q-bio]/Development Biology/Embryology and Organogenesis
3. Good health
EARLY-LIFE ADVERSITY
Neuropsychology and Physiological Psychology
Autism spectrum disorder
Prenatal Exposure Delayed Effects
[ SDV.NEU.NB ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
DEPRESSION-LIKE BEHAVIOR
Female
Maternal care
Psychology
Selective Serotonin Reuptake Inhibitors
Clinical psychology
DETERMINES MATERNAL-BEHAVIOR
medicine.medical_specialty
Serotonin
[SDV.SP.MED] Life Sciences [q-bio]/Pharmaceutical sciences/Medication
Cognitive Neuroscience
Serotonin reuptake inhibitor
Reproductive behavior
Development
Stress
behavioral disciplines and activities
03 medical and health sciences
Offspring
[SDV.SP.MED]Life Sciences [q-bio]/Pharmaceutical sciences/Medication
GONADAL HORMONE MODULATION
mental disorders
Sex differences
medicine
Animals
Humans
Social Behavior
Psychiatry
Mood Disorders
NEONATAL FLUOXETINE EXPOSURE
[ SDV.SP.MED ] Life Sciences [q-bio]/Pharmaceutical sciences/Medication
AUTISM SPECTRUM DISORDER
[SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
Play behavior
Epigenome
Perinatal depression
medicine.disease
Mental health
Social relation
030104 developmental biology
[SDV.BDD.EO]Life Sciences [q-bio]/Development Biology/Embryology and Organogenesis
[ SDV.BDD.EO ] Life Sciences [q-bio]/Development Biology/Embryology and Organogenesis
PITUITARY-ADRENAL AXIS
030217 neurology & neurosurgery
Perinatal Depression
Social behavior
Zdroj: Neuroscience and Biobehavioral Reviews
Neuroscience and Biobehavioral Reviews, 2018, 85, pp.102-116. ⟨10.1016/j.neubiorev.2017.04.023⟩
Neuroscience and Biobehavioral Reviews, Elsevier, 2018, 85, pp.102-116. ⟨10.1016/j.neubiorev.2017.04.023⟩
Neuroscience and Biobehavioral Reviews, Elsevier, 2017, 85, pp.102-116. 〈10.1016/j.neubiorev.2017.04.023〉
Neuroscience and Biobehavioral Reviews, 85, 102-116. Elsevier Science
ISSN: 0149-7634
1873-7528
DOI: 10.1016/j.neubiorev.2017.04.023⟩
Popis: International audience; Recent research has linked early life exposure to selective serotonin reuptake inhibitor medications (SSRIs) to modifications of social behaviors in children. Serotonin is a key regulator of neurodevelopment, social behaviors and mental health, and with the growing use of SSRIs to treat maternal affective disorders during the perinatal period, questions have been raised about the benefits and risks of perinatal SSRI exposure on the developing child. This review will highlight how perinatal SSRIs affect maternal care and neurodevelopmental outcomes related to social affiliative behaviors in offspring; such as play behaviors, social interactions, reproductive behaviors, and maternal care of the next generation. We will also review how early life exposure to SSRIs can alter related neurobiology, and the epigenome. Both clinical research and findings from animal models will be discussed. Understanding the impact of perinatal SSRIs on neurobehavioral outcomes will improve the health and well-being of subsequent generations.
Databáze: OpenAIRE
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