AnIn VivoandIn VitroComparison of Two Powder Inhalers following Storage at Hot/Humid Conditions
| Autor: | Peter Lipniunas, Lars Borgström, Lars Asking |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine Budesonide medicine.medical_specialty Hot Temperature Time Factors Lung deposition Drug Storage Biological Availability Pharmacology Pharmacokinetics Adrenal Cortex Hormones In vivo medicine Budesonide Formoterol Fumarate Drug Combination Humans Albuterol Pharmacology (medical) Particle Size Lung Cross-Over Studies Chemistry Nebulizers and Vaporizers Inhaler Humidity Crossover study Fluticasone-Salmeterol Drug Combination In vitro Bronchodilator Agents Bioavailability Surgery Androstadienes Drug Combinations Ethanolamines Area Under Curve Female Powders medicine.drug |
| Zdroj: | Journal of Aerosol Medicine. 18:304-310 |
| ISSN: | 1557-9026 0894-2684 |
| DOI: | 10.1089/jam.2005.18.304 |
| Popis: | Dry powder inhalers (DPIs) are increasingly being used for the treatment of asthma and COPD. A potential drawback is that DPIs can be sensitive to humidity. Two DPIs, Symbicort Turbuhaler and Seretide Diskus, were stored 3 months at either 25 degrees C/30% RH or 40 degrees C/75% RH. After storage, delivered, as well as fine particle dose, FPD, were tested in vitro and lung deposition, of the steroid components, was assessed in vivo. After storage at 40 degrees C/75% RH, delivered dose as well as FPD from Symbicort Turbuhaler was virtually unchanged while FPD for Seretide Diskus decreased by about 50% despite no decrease in delivered dose. For both products, no difference in FPD was seen after storage at 25 degrees C/30% RH. These in vitro findings were confirmed in the in vivo part of the study. Lung deposition for Symbicort Turbuhaler was unaffected by 40 degrees C/75% RH storage, while for Seretide Diskus it was reduced with about 50%. The study extends previous in vitro observations of impaired performance of Seretide Diskus and demonstrates that this translates into decreased drug delivery to the site of action. The clinical importance of this finding has not been studied but could result in undertreatment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|