Expression of the Annexin A1 and its correlation with matrix metalloproteinases and the receptor for formylated peptide-2 in diffuse astrocytic tumors
| Autor: | Ana Paula Girol, Matheus Vicente Mayorquim, Melina Mizusaki Iyomasa-Pilon, Maryam Buainain Tadei, Mairto Roberis Geromel, Sara de Souza Costa, Helena Ribeiro Souza, Camila Brambilla de Souza, Lucas Possebon |
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| Přispěvatelé: | University Center Padre Albino (UNIFIPA), Universidade Estadual Paulista (Unesp) |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine endocrine system Pathology medicine.medical_specialty Peptide Astrocytoma Matrix metalloproteinase Malignancy Pathology and Forensic Medicine Correlation 03 medical and health sciences 0302 clinical medicine Biomarkers Tumor medicine Humans Receptors Lipoxin Receptor neoplasms Aged Annexin A1 chemistry.chemical_classification Brain Neoplasms General Medicine Middle Aged medicine.disease Metalloproteinases Receptors Formyl Peptide nervous system diseases 030104 developmental biology Matrix Metalloproteinase 9 chemistry 030220 oncology & carcinogenesis Matrix Metalloproteinase 2 Female Glioblastomas FPR Immunostaining Astrocytomas Anaplastic astrocytoma |
| Zdroj: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| ISSN: | 1092-9134 |
| DOI: | 10.1016/j.anndiagpath.2018.08.002 |
| Popis: | Made available in DSpace on 2019-10-06T15:58:24Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-12-01 Astrocytomas represent the majority of cerebral gliomas. Studies show that the anti-inflammatory protein Annexin-A1 (ANXA1) is associated with the tumor invasion process and that its actions can be mediated by the receptor for formylated peptides (FPR). Therefore, we evaluated the expression of ANXA1, the receptor FPR2 and matrix metalloproteinases 2 and 9 (MMP-2 and MMP-9) in brain astrocytomas. Detection of proteins was performed in sections of diffuse astrocytomas (grade II), anaplastic astrocytomas (grade III) and glioblastomas (GBM, grade IV) and quantifications were made by densitometry. Our analyses showed increased expression of ANXA1 in astrocytomas of all grades, but especially in GBM. The expression of FPR2 is similar to that found for ANXA1, being higher in GBM. Immunostaining for MMPs is also stronger as the degree of malignancy increases, especially with respect to MMP-9. The positive correlation between ANXA1/FPR2 and ANXA1/MMP-9 was observed in all tumors studied. The data indicate the possible action of ANXA1 and FPR2 on the development and progression of astrocytomas, related to increased expression of MMP-9. Thereby, ANXA1 and FPR2 are involved in the biology and malignancy of diffuse astrocytic tumors. University Center Padre Albino (UNIFIPA) São Paulo State University (UNESP) Institute of Biosciences Humanities and Exact Sciences (Ibilce) Department of Biology Laboratory of Immunomorphology, São José do Rio Preto Campus São Paulo State University (UNESP) Institute of Biosciences Humanities and Exact Sciences (Ibilce) Department of Biology Laboratory of Immunomorphology, São José do Rio Preto Campus |
| Databáze: | OpenAIRE |
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