Endothelial VE-cadherin expression in human lungs
| Autor: | Martina C. Herwig, Klaus-Michael Müller, Annette M. Müller |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty ARDS Adolescent Endothelium Pulmonary Artery Pathology and Forensic Medicine Pathogenesis Sex Factors Venules Antigens CD medicine Humans Child Lung Pathological Aged biology Cell adhesion molecule Age Factors Infant Cell Biology Middle Aged Cadherins medicine.disease Capillaries Endothelial stem cell Arterioles medicine.anatomical_structure Pulmonary Veins Child Preschool biology.protein Female Endothelium Vascular VE-cadherin Antibody |
| Zdroj: | Pathology - Research and Practice. 204:725-730 |
| ISSN: | 0344-0338 |
| DOI: | 10.1016/j.prp.2008.04.014 |
| Popis: | Cell adhesion molecule vascular endothelial cadherin (VE-cadherin) is the major component of endothelial adherence junctions, maintaining endothelial cell integrity. Studies dealing with constitutive VE-cadherin expression patterns in different pulmonary vessel types (arteries, arterioles, capillaries, venules, veins) or with the influence of physiological factors such as age or sex on VE-cadherin expression have not been published yet. Knowledge of constitutive resp. varying expression patterns not only fundamentally contribute to understanding the role of VE-cadherin in the pathogenesis of pulmonary diseases but also help to develop therapies based on immunotargeting. Hence, endothelial VE-cadherin expression was studied in regular lung tissue. Fifty-eight specimens of regular lung tissue (30 females, 28 males between 1 month and 75 years old) were immunohistochemically stained with an antibody against VE-cadherin. There was strong endothelial expression of VE-cadherin in arteries, arterioles, and capillaries but almost no expression in veins and venules. Neither age nor sex had any influence on the expression pattern or staining intensity. There is a vessel type-specific expression pattern for VE-cadherin in regular human lung tissue, which is not influenced by age or sex. Further studies will have to prove whether this is influenced by pathological conditions, e.g., ARDS. |
| Databáze: | OpenAIRE |
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