Synthesis and antibacterial activity of [6,5,5] and [6,6,5] tricyclic fused oxazolidinones

Autor:	K. D. Lovasz, D. M. Gleave, Gary E. Zurenko, D. C. Rohrer, Manninen Peter Rudolph, John A. Tucker, D. A. Allwine, Steven J. Brickner, Ford Charles W
Rok vydání:	1999
Předmět:	Models Molecular Molecular model Stereochemistry medicine.drug_class Clinical Biochemistry Molecular Conformation Pharmaceutical Science Carboxamide Microbial Sensitivity Tests Biochemistry Chemical synthesis Mice Structure-Activity Relationship Drug Discovery medicine Structure–activity relationship Animals Molecular Biology Oxazoles Antibacterial agent chemistry.chemical_classification Bacteria Molecular Structure Chemistry Organic Chemistry Bacterial Infections Anti-Bacterial Agents Molecular Medicine Indicators and Reagents Enantiomer Antibacterial activity Tricyclic
Zdroj:	Bioorganicmedicinal chemistry letters. 8(10)
ISSN:	0960-894X
Popis:	A series of conformationally restricted, [6,5,5] and [6,6,5] tricyclic fused oxazolidinones were synthesized and tested for antibacterial activity. Several compounds in the trans-[6,5,5] series demonstrated potent in vitro and in vivo activity. This work provides valuable information regarding the preferred conformational orientation of the oxazolidinones at the binding site.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a63cd76ca19684f30132594755dd09b2 https://pubmed.ncbi.nlm.nih.gov/9871741 Zobrazit plný text záznamu Full Text from ScienceDirect