Oxidative stress, microsomal and peroxisomal fatty acid oxidation in the liver of rats treated with acetone
| Autor: | Viviana Guajardo, Lilian Thieleman, Julia Araya, Myriam Orellana B, Ramón Rodrigo |
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| Rok vydání: | 2001 |
| Předmět: |
Male
Physiology Health Toxicology and Mutagenesis Toxicology Biochemistry Acetone Superoxide dismutase chemistry.chemical_compound Peroxisomes Animals Rats Wistar Beta oxidation chemistry.chemical_classification biology Glutathione peroxidase Fatty Acids Cell Biology General Medicine Glutathione Peroxisome Malondialdehyde Lauric acid Rats Oxidative Stress chemistry Microsomes Liver biology.protein Ketone bodies |
| Zdroj: | COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY PART C PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY Artículos CONICYT CONICYT Chile instacron:CONICYT |
| ISSN: | 1532-0456 |
| DOI: | 10.1016/s1532-0456(01)00171-5 |
| Popis: | Parameters of oxidative stress, microsomal cytochrome P450 activity and peroxisomal fatty acid oxidation were studied in liver of rats following acetone (1% v/v) consumption for 7 days. Acetone treatment increased the activity of catalase and decreased the activities of superoxide dismutase (SOD) and glutathione peroxidase (GTPx), but did not significantly modify the liver content of malondialdehyde (MDA) and reduced glutathione. Also, acetone increased the total content of cytochrome P450, the microsomal lauric acid hydroxylation, aminopyrine N-demethylation and the peroxisomal beta-oxidation of palmitoyl CoA. These effects were similar to those found previously in starved and ethanol-treated rats, supporting the hypothesis that ketone bodies would be the common inducer of microsomal and peroxisomal fatty acid oxidation in these metabolic states. |
| Databáze: | OpenAIRE |
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