Gentamicin-Loaded Wound Dressing With Polyvinyl Alcohol/Dextran Hydrogel: Gel Characterization and In Vivo Healing Evaluation
| Autor: | Jeong Hoon Lee, Jung-Ae Kim, Jong Oh Kim, Ma-Ro Hwang, Sung Soo Han, Chul Soon Yong, Sun Woo Chang, Sae-Kwang Ku, Sung Gju Jin, Han-Gon Choi, Jeong Hoon Kim, Yong-Il Kim, Won Seok Lyoo |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Administration Topical Pharmaceutical Science Wounds Penetrating Aquatic Science Polyvinyl alcohol Rats Sprague-Dawley Wound care chemistry.chemical_compound Drug Discovery Polymer chemistry Ultimate tensile strength medicine Animals Ecology Evolution Behavior and Systematics Drug Carriers Wound Healing integumentary system Ecology Dextrans Hydrogels General Medicine Bandages Anti-Bacterial Agents Rats Treatment Outcome Dextran chemistry Polyvinyl Alcohol Self-healing hydrogels Gentamicins Swelling medicine.symptom Wound healing Agronomy and Crop Science Research Article Protein adsorption Biomedical engineering |
| Zdroj: | AAPS PharmSciTech. 11:1092-1103 |
| ISSN: | 1530-9932 |
| DOI: | 10.1208/s12249-010-9474-0 |
| Popis: | To develop a gentamicin-loaded wound dressing, cross-linked hydrogel films were prepared with polyvinyl alcohol (PVA) and dextran using the freezing–thawing method. Their gel properties such as gel fraction, swelling, water vapor transmission test, morphology, tensile strength, and thermal property were investigated. In vitro protein adsorption test, in vivo wound healing test, and histopathology were performed. Dextran decreased the gel fraction, maximum strength, and thermal stability of hydrogels. However, it increased the swelling ability, water vapor transmission rate, elasticity, porosity, and protein adsorption. The drug gave a little positive effect on the gel properties of hydrogels. The gentamicin-loaded wound dressing composed of 2.5% PVA, 1.13% dextran, and 0.1% drug was more swellable, flexible, and elastic than that with only PVA because of its cross-linking interaction with PVA. In particular, it could provide an adequate level of moisture and build up the exudates on the wound area. From the in vivo wound healing and histological results, this gentamicin-loaded wound dressing enhanced the healing effect more compared to conventional product because of the potential healing effect of gentamicin. Thus, this gentamicin-loaded wound dressing would be used as a potential wound dressing with excellent forming and improved healing effect in wound care. |
| Databáze: | OpenAIRE |
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