Microparticulated Hydrochlorothiazide Solid Dispersion: Enhancing Dissolution Properties via Spray Drying

Autor: Rodrigo M. Martins, Simone Vieira Pereira, M. O. Machado, A. B. F. L. Nosari, Luciana A. Tacon, Luís Alexandre Pedro de Freitas
Rok vydání: 2012
Předmět:
Zdroj: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
ISSN: 1532-2300
0737-3937
DOI: 10.1080/07373937.2011.652268
Popis: The aim of the present study was to obtain microparticles of hydrochlorothiazide, a diuretic drug that practically insoluble in water, by spray drying and to investigate the influence of process parameters using a three-level, three-factor Box-Behnken design. Process yields, moisture content, particle size, flowability, and solubility were used to evaluate the spray-dried microparticles. The data were analyzed by response surface methodology using analysis of variance. The independent variables studied were outlet temperature, atomization pressure, and drug content. The formulations were prepared using polyvinylpyrrolidone and colloidal silicon dioxide as the hydrophilic carrier and drying aid, respectively. The microparticle yield ranged from 18.15 to 59.02% and resulted in adequate flow (17 to 32°), moisture content between 2.52 to 6.18%, and mean particle size from 45 to 59 µm. The analysis of variance showed that the factors studied influenced the yields, moisture content, angle of repose, and solubil...
Databáze: OpenAIRE
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