Calcitonin Levels Do Not Decrease with Weaning in Chronic Alcoholism
| Autor: | Catherine Cardot-Bauters, L. Leclerc, J.-L. Wémeau, Michèle d’Herbomez, Thierry Danel, Marie-Christine Vantyghem, Bruno Carnaille, S. Marcelli-Tourvieille, C. Docao, J. Moriau |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Calcitonin Male Drug medicine.medical_specialty Adolescent Alcohol Drinking Endocrinology Diabetes and Metabolism media_common.quotation_subject Physiology Acute effect Endocrinology Internal medicine Chronic alcoholism Humans Medicine Weaning Prospective Studies Aged media_common business.industry Middle Aged Substance Withdrawal Syndrome Alcoholism Calcium Female business |
| Zdroj: | Thyroid. 17:213-217 |
| ISSN: | 1557-9077 1050-7256 |
| DOI: | 10.1089/thy.2006.0216 |
| Popis: | Alcohol might increase calcitonin but this assertion is mainly based on the acute effect of the drug in small animals and humans. The aim of this study was to investigate the effect of chronic alcoholic intoxication on plasma calcitonin (CT) levels.20 smoking male subjects admitted to be weaned from chronic daily alcohol consumption100 g were included after informed consent. Blood was sampled upon admission (T0) and after 5 (T5) and 21 (T21) days of alcohol weaning to measure mean erythrocyte volume, gamma-glutamyltransferase (GGT), calcium, gastrin, and CT levels. The control group consisted of 30 male subjects with daily alcohol consumption20 g.The characteristics of the alcohol group were as follows (mean +/- SD): age 41.2 +/- 13 years old; mean erythrocyte volume: 96.0 +/- 4.2 microm(3) (N: 85-95); calcium level: 94.7 +/- 3.7 mg/L (N: 85-105); gastrinemia: 59.3 +/- 14.9 ng/mL (N:120). At T0 and T21, three alcoholic subjects had CT levels above 10 pg/mL, usually considered as the normal cut-off value. There was no correlation between CT and the different biochemical parameters at T0, T5, and T21. There was no difference between CT levels at the different stages in the alcohol group (T0: 6.4 +/- 3.6 pg/mL; T5: 6.5 +/- 5.3 pg/mL; T21: 8.4 +/- 5.6), although GGT significantly decreased with weaning duration (T0: 248 +/- 354 IU/L; T5: 211 +/- 290 IU/L; T21: 79 +/- 90 IU/L; ANOVA, p0.05). But a significant difference was found between mean CT levels in the alcohol group and in the control group (3.1 +/- 0.7 pg/mL, p0.0001).This study suggests that mean CT levels of chronically alcoholic smoking male subjects are higher than those of an age- and sex-matched control group. However, most alcoholic patients exhibited CT levels10 pg/mL. No decrease in CT levels was noted over a short period of alcohol weaning. As CT measurement is currently recommended in thyroid nodule assessment, this finding may be important to know how to decipher borderline values of CT. |
| Databáze: | OpenAIRE |
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