Multiple co-infections (Mycoplasma, Chlamydia, human herpes virus-6) in blood of chronic fatigue syndrome patients: association with signs and symptoms
| Autor: | R. Gan, G. L. Nicolson, J. Haier |
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| Rok vydání: | 2003 |
| Předmět: |
Microbiology (medical)
Adult DNA Bacterial Male medicine.medical_specialty Adolescent Herpesvirus 6 Human Roseolovirus Infections Mycoplasmataceae medicine.disease_cause Polymerase Chain Reaction Pathology and Forensic Medicine Mycoplasma Internal medicine Chronic fatigue syndrome medicine Immunology and Allergy Humans Chlamydiaceae Mycoplasma Infections Chlamydia Aged Fatigue Syndrome Chronic biology Base Sequence Incidence (epidemiology) General Medicine Chlamydia Infections Middle Aged medicine.disease biology.organism_classification Chlamydiales Case-Control Studies Immunology DNA Viral Human herpesvirus 6 Female |
| Zdroj: | APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. 111(5) |
| ISSN: | 0903-4641 |
| Popis: | Nicolson GL, Gan R, Haier J. Multiple co-infections (Mycoplasma, Chlamydia, human herpes virus-6) in blood of chronic fatigue syndrome patients: association with signs and symptoms. APMIS 2003;111:557–66. Previously we and others found that a majority of chronic fatigue syndrome (CFS) patients showed evidence of systemic mycoplasmal infections, and their blood tested positive using a polymerase chain reaction assay for at least one of the four following Mycoplasma species: M. fermentans, M. hominis, M. pneumoniae or M. penetrans. Consistent with previous results, patients in the current study (nΩ200) showed a high prevalence (overall 52%) of mycoplasmal infections. Using forensic polymerase chain reaction we also examined whether these same patients showed evidence of infections with Chlamydia pneumoniae (overall 7.5% positive) and/or active human herpes virus-6 (HHV-6, overall 30.5% positive). Since the presence of one or more infections may predispose patients to other infections, we examined the prevalence of C. pneumoniae and HHV-6 active infections in mycoplasma-positive and -negative patients. Unexpectedly, we found that the incidence of C. pneumoniae or HHV-6 was similar in Mycoplasma-positive and -negative patients, and the converse was also found in active HHV-6-positive and -negative patients. Control subjects (nΩ100) had low rates of mycoplasmal (6%), active HHV-6 (9%) or chlamydial (1%) infections, and there were no co-infections in control subjects. Differences in bacterial and/or viral infections in CFS patients compared to control subjects were significant. Severity and incidence of patients’ signs and symptoms were compared within the above groups. Although there was a tendency for patients with multiple infections to have more severe signs and symptoms (p0.01), the only significant differences found were in the incidence and severity of certain signs and symptoms in patients with multiple co-infections of any type compared to the other groups (p0.01). There was no correlation between the type of co-infection and severity of signs and symptoms. The results indicate that a large subset of CFS patients show evidence of bacterial and/or viral infection(s), and these infections may contribute to the severity of signs and symptoms found in these patients. |
| Databáze: | OpenAIRE |
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