Altered left ventricular twist is associated with clinical severity in adults and adolescents with homozygous sickle cell anemia
| Autor: | Danielen Cristina Mariano Peluccio, Fábio Villaça Guimarães Filho, Amanda Guerra de Moraes Rego Sousa, Igor Ribeiro de Castro Bienert, Paulo H. Waib, Doralice Marvulle Tan, Alexandre Rodrigues, Joao Carlos Moron Saes Braga, Fernanda Di Tullio Trindade Vilela, Jorge Eduardo Assef, Rodrigo Barretto |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Torsion Abnormality Heart Ventricles Speckle tracking echocardiography Anemia Sickle Cell Sensitivity and Specificity Severity of Illness Index Ventricular Dysfunction Left medicine.artery Internal medicine Severity of illness medicine Humans Radiology Nuclear Medicine and imaging Twist Ejection fraction business.industry Reproducibility of Results medicine.disease Sickle cell anemia medicine.anatomical_structure Blood pressure Ventricle Echocardiography Pulmonary artery Cardiology Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography. 28(6) |
| ISSN: | 1097-6795 |
| Popis: | Sickle cell anemia (SCA) is associated with cardiac abnormalities and premature death. The aims of this study were to identify early markers of cardiac dysfunction through ventricular strain and ventricular twist and determine the relationships between these measures and other markers of cardiovascular risk.Forty patients with SCA (mean age, 23.5 ± 9.3 years; 24 male patients) and 40 age- and sex-matched healthy individuals were compared. All subjects participated in structured interviews, and blood samples were collected. Standard echocardiography with subsequent offline evaluations using left ventricular (LV) and right ventricular systolic strain and rotational analyses of the left ventricle using two-dimensional speckle-tracking echocardiography were performed.There were no differences in LV ejection fraction, global LV strain (longitudinal, circumferential, and radial), and global right ventricular longitudinal strain between patients and controls; however, LV twist was significantly lower in the patient group (mean, 7.4 ± 1.2° vs 10.7 ± 1.8°; P .0001). Several variables were strongly related to LV twist, including the clinical severity index (ρ = -0.97, Z score = -6.05, P .0001), E/e' ratio (r = 0.78, P .0001), LV end-diastolic volume index (r = 0.81, P .0001), and pulmonary artery systolic pressure (r = 0.72, P .0001).LV twist is altered in patients with SCA. There were strong correlations between left ventricular twist and clinical severity index, E/e' ratio, LV end-diastolic volume index, and pulmonary artery systolic pressure. These data suggest that decreased LV twist may indicate a subgroup of patients with SCA at greater cardiac risk. |
| Databáze: | OpenAIRE |
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