Targeting Bacterial Sortase A with Covalent Inhibitors: 27 New Starting Points for Structure-Based Hit-to-Lead Optimization

Autor:	Ainars Leonchiks, Raitis Bobrovs, Atis Je Kabsons, Kristaps Jaudzems, Viktorija Kurbatska, Zhanna Rudevica
Rok vydání:	2019
Předmět:	0301 basic medicine Staphylococcus aureus Magnetic Resonance Spectroscopy Antivirulence Virulence Factors 030106 microbiology Small Molecule Libraries 03 medical and health sciences Mice Bacterial Proteins Catalytic Domain Drug Discovery Animals chemistry.chemical_classification Binding Sites Chemistry Hit to lead Fibroblasts Aminoacyltransferases Anti-Bacterial Agents Molecular Docking Simulation Cysteine Endopeptidases 030104 developmental biology Infectious Diseases Enzyme Biochemistry Covalent bond Sortase A Bacterial virulence NIH 3T3 Cells Structure based
Zdroj:	ACS infectious diseases. 6(2)
ISSN:	2373-8227
Popis:	Because of its essential role as a bacterial virulence factor, enzyme sortase A (SrtA) has become an attractive target for the development of new antivirulence drugs against Gram-positive infections. Here we describe 27 compounds identified as covalent inhibitors of
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a630a18ece14a813ee9b15db76348618 https://pubmed.ncbi.nlm.nih.gov/31724850 Zobrazit plný text záznamu