Adverse drug reactions and kinetics of cisplatin excretion in urine of patients undergoing cisplatin chemotherapy and radiotherapy for head and neck cancer: a prospective study
| Autor: | Eder de Carvalho Pincinato, Graziele Baldan Ferrari, Patricia Moriel, Carmen Silvia Passos Lima, Marília Berlofa Visacri, Priscila Gava Mazzola, Júlia Coelho França Quintanilha |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Oncology Male medicine.medical_specialty Nausea medicine.medical_treatment Adverse drug reaction Excretion Antineoplastic Agents Urine Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine Lymphopenia Medicine Chemotherapy Humans Prospective Studies Head and neck cancer Cisplatin business.industry Common Terminology Criteria for Adverse Events Anemia Pharyngeal Neoplasms Building and Construction Chemoradiotherapy Middle Aged medicine.disease 030104 developmental biology Head and Neck Neoplasms 030220 oncology & carcinogenesis Female medicine.symptom business medicine.drug Research Article |
| Zdroj: | DARU Journal of Pharmaceutical Sciences |
| ISSN: | 2008-2231 1560-8115 |
| Popis: | Background Cisplatin is a high-potency anticancer agent; however, it causes significant adverse drug reactions (ADRs). Potential pharmacokinetic markers must be studied to predict or prevent cisplatin-induced ADRs and achieve better prognosis. This study was designed to investigate the relationship between ADRs and kinetics of cisplatin excretion in the urine of patients undergoing high-dose cisplatin chemotherapy and radiotherapy for head and neck cancer. Methods Outpatients with head and neck cancer received a first cycle of high-dose cisplatin chemotherapy (80–100 mg/m2) concurrent to radiotherapy. ADRs (haematological, renal, and gastrointestinal reactions) were classified based on severity by National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE, version 4, grade 0–4). The kinetics of cisplatin excretion in urine was evaluated by high-performance liquid chromatography over three time periods: 0–12, 12–24, and 24–48 h after the administration of cisplatin. Spearman Correlation test and regression analysis were performed to assess the relationship between ADRs and cisplatin excretion in the urine. Results In total, 59 patients with a mean age of 55.6 ± 9.4 years were analysed; most patients were male (86.4%), white (79.7%), and with pharyngeal tumours in advanced stages (66.1%). The most frequently observed ADRs were anaemia (81.4%), lymphopenia (78%), and nausea (64.4%); mostly grades 1 and 2 of toxicity. The mean cisplatin excretion was 70.3 ± 64.4, 7.3 ± 6.3, and 5 ± 4 μg/mg creatinine at 0–12, 12–24, and 24–48 h, respectively. Statistical analysis showed that the amount of cisplatin excreted did not influence the severity of ADRs. Conclusions The most frequent ADRs were anaemia, lymphopenia, and nausea. Grades 1 and 2 were the severities for most ADRs. The period over which the highest cisplatin excretion observed was 0–12 h after chemotherapy, and cisplatin excretion could not predict toxicity. Graphical abstract |
| Databáze: | OpenAIRE |
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