The Prognostic Significance of Novel Pancreas Cancer Prognostic Index in Unresectable Locally Advanced Pancreas Cancers Treated with Definitive Concurrent Chemoradiotherapy
| Autor: | Erkan Topkan, Veysel Haksoyler, Berrin Pehlivan, Nulifer Kilic Durankus, Yasemin Bolukbasi, Duygu Sezen, Ugur Selek, Ahmet Kucuk |
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| Přispěvatelé: | Sezen, Duygu (ORCID 0000-0002-4505-2280 & YÖK ID 170535), Selek, Uğur (ORCID 0000-0001-8087-3140 & YÖK ID 27211), Durankuş, Nülifer Kılıç, Bölükbaşı, Yasemin (ORCID 0000-0002-3170-5826 & YÖK ID 216814), Topkan, Erkan, Pehlivan, Berrin, Küçük, Ahmet, Haksöyler, Veysel, School of Medicine |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
survival outcomes Locally advanced pancreas cancer Concurrent chemoradiotherapy Prognosis Survival outcomes Pancreas cancer prognostic index Immunology Locally advanced Gastroenterology concurrent chemoradiotherapy Internal medicine medicine Immunology and Allergy Original Research Receiver operating characteristic business.industry Curve analysis Cancer medicine.disease Confidence interval locally advanced pancreas cancer medicine.anatomical_structure Pancreas Cancers prognosis pancreas cancer prognostic index Pancreas business Journal of Inflammation Research |
| Zdroj: | Journal of Inflammation Research |
| ISSN: | 1178-7031 |
| Popis: | Purpose: we evaluated the prognostic quality of the novel pancreas cancer prognostic index (PCPI), a combination of CA 19-9 and systemic inflammation response index (SIRI), on the outcomes of locally advanced pancreas adenocarcinoma (LAPAC) patients who received concurrent chemoradiotherapy (C-CRT). Methods: this retrospective analysis covered 152 unresectable LAPAC patients treated from 2007 to 2019. Receiver operating characteristic (ROC) curve analysis was used to define ideal cutoff thresholds for the pretreatment CA 19-9 and SIRI measurements, indivi-dually. The associations between the PCPI groups and progression -free-(PFS) and overall survival (OS) comprised the respective primary and secondary endpoints. Results: the ROC curve analysis distinguished the respective rounded optimal cutoffs at 91 U/m/ L (< versus >= 90) and 1.8 (< versus >= 1.8) for CA 19-9 and SIRI, arranging the study cohort into two significantly different survival groups for each, with resultant four likely groups: Group-1: CA 19-9= 1.8, Group-3: CA 19-9 >= 90 U/ m/L but SIRI= 90 U/m/L and SIRI >= 1.8. Since the PFS (P=0.79) and OS (P=0.86) estimates of the groups 2 and 3 were statistically indistinct, we merged them as one group and created the novel three-tiered PCPI: PCPI-1: CA 19-9= 1.8 or CA 19-9 >= 90 U/m/L but SIRI= 90 U/m/L and SIRI >= 1.8, respectively. Comparative analyses unveiled that the PCPI-1 and PCPI-3 groups had the respective best and worst PFS (17.0 versus 7.5 versus 4.4 months; P NA |
| Databáze: | OpenAIRE |
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