Identification of LSD Derivatives, 1cP-LSD, MIPLA and 1B-LSD in Illegal Products as Paper Sheet
| Autor: | Takashi Hakamatsuka, Maiko Kawamura, Ruri Kikura-Hanajiri, Rie Tanaka |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Paper
Hallucinogen Magnetic Resonance Spectroscopy medicine.drug_class Pharmaceutical Science 030226 pharmacology & pharmacy 01 natural sciences Gas Chromatography-Mass Spectrometry Mass Spectrometry Designer Drugs 03 medical and health sciences 0302 clinical medicine Ergot alkaloid medicine Organic chemistry Lysergic acid diethylamide Dosage Forms Pharmacology Paper sheet Illicit Drugs 010405 organic chemistry Chemistry 0104 chemical sciences Designer drug Lysergic Acid Diethylamide Lysergamide Hallucinogens Chromatography Liquid medicine.drug |
| Zdroj: | YAKUGAKU ZASSHI. 140:1405-1413 |
| ISSN: | 1347-5231 0031-6903 |
| DOI: | 10.1248/yakushi.20-00124 |
| Popis: | Lysergic acid diethylamide (LSD) is a hallucinogen, synthesized from ergot alkaloid, and controlled as a narcotic in Japan. Recently, LSD derivatives have appeared as designer drugs, all over the world. In previous study, we reported identification and analysis of four LSD derivatives in four paper sheet products. In this study, we detected three additional LSD derivatives from three paper sheet products, which were obtained from September 2019 to March 2020 in Japan. We extracted the compounds from paper sheet products with methanol for LC-MS, high-resolution MS and GC-MS analyses. The compounds were identified as 4-cyclopropionyl-N,N-diethyl-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide (1cP-LSD), N-methyl-N-isopropyl-7-methyl-4,6,6a,7,8,9-hexahydroindolo-[4,3-fg]quinoline-9-carboxamide (MIPLA), 4-butyryl-N,N-diethyl-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide (1B-LSD), by GC-MS, LC-MS, LC-Q-TOF-MS and NMR analyses. As well as other N1-acylated LSD derivatives, 1cP-LSD and 1B-LSD were easily deacylated to LSD during GC-MS analysis, we have to be careful to analyze these compounds. |
| Databáze: | OpenAIRE |
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