Aortic pulse wave velocity in individuals of Asian and African ancestry: the HELISUR study
| Autor: | Lizzy M. Brewster, Lenny M W Nahar-van Venrooij, Frederieke S. Diemer, Bert Jan H. van den Born, Ron J.G. Peters, Se Sergio M. Baldew, Fares A. Karamat, Gert A. van Montfrans, Yentl C. Haan, Glenn P. Oehlers |
|---|---|
| Přispěvatelé: | ACS - Atherosclerosis & ischemic syndromes, Graduate School, Cardiology, Vascular Medicine, Amsterdam Reproduction & Development (AR&D), ACS - Pulmonary hypertension & thrombosis, ACS - Heart failure & arrhythmias |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Waist Pulse Wave Analysis 030204 cardiovascular system & hematology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Asian People Risk Factors Internal medicine Total cholesterol Internal Medicine medicine Humans 030212 general & internal medicine Pulse wave velocity Aged Suriname Multivariable linear regression business.industry Cholesterol Coronary heart disease Cross-Sectional Studies Blood pressure chemistry Cardiology business |
| Zdroj: | Journal of human hypertension, 34(2), 108-116. Nature Publishing Group |
| ISSN: | 1476-5527 0950-9240 |
| DOI: | 10.1038/s41371-018-0144-0 |
| Popis: | Aortic pulse wave velocity has emerged as an important predictor of cardiovascular events, but data on ethnic differences in pulse wave velocity remain scarce. We explored differences in pulse wave velocity between people of Asian and African ancestry. Data were used from the cross-sectional Healthy Life in Suriname (HELISUR) study. Pulse wave velocity was estimated oscillometrically with the Arteriograph. We included 353 Asians and 364 Africans, aged respectively 44.9 (SD 13.5) and 42.8 (SD 14.1) years (p = 0.05). Crude median PWV was higher in Asians than in Africans (8.1 [IQR 6.9–10.1] m/s vs. 7.7 [IQR 6.5–9.3] m/s, p = 0.03), which was mainly attributable to an increased PWV in Asians ≥ 50 years (10.1 [IQR 8.7–11.8] m/s vs. 9.1 [IQR 7.9–11.3] m/s in Africans ≥50 years, p < 0.01). After adjustment for age and MAP in multivariable linear regression, Asians had a 1.044 [95% CI 1.019–1.072] m/s higher PWV compared to Africans. Additional adjustment for sex, glucose, total cholesterol, HDL cholesterol, triglycerides, BMI, and waist circumference did not substantially change the difference in pulse wave velocity between Asians and Africans (+1.044 [95% CI 1.016–1.074] m/s for Asians vs. Africans). In conclusion, persons of Asian ancestry have a higher pulse wave velocity than those of African ancestry. This persisted after adjustment for important cardiovascular risk parameters, including age and blood pressure. The higher PWV found in Asians could be consistent with their increased coronary heart disease risk. |
| Databáze: | OpenAIRE |
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