Large-Vessel Vasculitis: Interobserver Agreement and Diagnostic Accuracy of 18F-FDG-PET/CT

Autor: K. D. F. Lensen, A. T. Zwijnenburg, Elisabeth Brouwer, Riemer H. J. A. Slart, C.J. van der Laken, Andor W. J. M. Glaudemans, Yvo M. Smulders, Emile F.I. Comans, Alexandre E. Voskuyl, L. M. Pereira Arias-Bouda
Přispěvatelé: Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Translational Immunology Groningen (TRIGR), Vascular Ageing Programme (VAP), Cardiovascular Centre (CVC), ​Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE), Internal medicine, Radiology and nuclear medicine, Rheumatology, CCA - Disease profiling, ICaR - Circulation and metabolism
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Male
lcsh:Medicine
Femoral artery
ANGIOGRAPHY
DISEASE
Observer Variation
medicine.diagnostic_test
General Medicine
Arteries
ARCH
Positron emission tomography
Female
Radiology
Vasculitis
Research Article
medicine.medical_specialty
Article Subject
Giant Cell Arteritis
POLYMYALGIA-RHEUMATICA
Sensitivity and Specificity
General Biochemistry
Genetics and Molecular Biology
Polymyalgia rheumatica
POSITRON-EMISSION-TOMOGRAPHY
INFLAMMATION
Fluorodeoxyglucose F18
GIANT-CELL ARTERITIS
Large vessel vasculitis
medicine.artery
medicine
Humans
Aged
General Immunology and Microbiology
business.industry
lcsh:R
Reproducibility of Results
medicine.disease
Atherosclerosis
AORTIC INVOLVEMENT
carbohydrates (lipids)
Giant cell arteritis
PET
Positron-Emission Tomography
Angiography
Radiopharmaceuticals
business
Nuclear medicine
Tomography
X-Ray Computed
FOLLOW-UP
Kappa
Zdroj: BioMed Research International, Vol 2015 (2015)
Lensen, K D F, Comans, E F I, Voskuyl, A E, van der Laken, C J, Brouwer, E, Zwijnenburg, A T, Arias-Bouda, L M P, Glaudemans, A W J M, Slart, R H J A & Smulders, Y M 2015, ' Large-Vessel Vasculitis: Interobserver Agreement and Diagnostic Accuracy of F-18-FDG-PET/CT ', BioMed Research International, vol. 2015, 914692 . https://doi.org/10.1155/2015/914692
Biomed Research International, 2015:914692. HINDAWI LTD
BioMed Research International
BioMed Research International, 2015:914692. Hindawi Publishing Corporation
ISSN: 2314-6141
2314-6133
DOI: 10.1155/2015/914692
Popis: Introduction.18F-FDG-PET visualises inflammation. Both atherosclerosis and giant cell arteritis cause vascular inflammation, but distinguishing the two may be difficult. The goal of this study was to assess interobserver agreement and diagnostic accuracy of18F-FDG-PET for the detection of large artery involvement in giant cell arteritis (GCA).Methods. 3118F-FDG-PET/CT scans were selected from 2 databases. Four observers assessed vascular wall18F-FDG uptake, initially without and subsequently with predefined observer criteria (i.e., vascular wall18F-FDG uptake compared to liver or femoral artery18F-FDG uptake). External validation was performed by two additional observers. Sensitivity and specificity of18F-FDG-PET were determined by comparing scan results to a consensus diagnosis.Results. The highest interobserver agreement (kappa: 0.96 in initial study and 0.79 in external validation) was observed when vascular wall18F-FDG uptake higher than liver uptake was used as a diagnostic criterion, although agreement was also good without predefined criteria (kappa: 0.68 and 0.85). Sensitivity and specificity were comparable for these methods. The criterion of vascular wall18F-FDG uptake equal to liver18F-FDG uptake had low specificity.Conclusion. Standardization of image assessment for vascular wall18F-FDG uptake promotes observer agreement, enables comparative studies, and does not appear to result in loss of diagnostic accuracy compared to nonstandardized assessment.
Databáze: OpenAIRE
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