Response in chronic schizophrenia correlated with chlorpromazine, 7-OH-chlorpromazine and chlorpromazine sulfoxide levels
| Autor: | R. Miller, V.L. Pillay, S. V. Moodley, M. Chetty |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Drug
Adult Male Adolescent Chlorpromazine Metabolite media_common.quotation_subject Chlorpromazine sulfoxide Pharmacology chemistry.chemical_compound Medicine Humans Pharmacology (medical) Biological Psychiatry media_common business.industry Therapeutic effect Sulfoxide Metabolism Middle Aged Psychiatry and Mental health Logistic Models Neurology chemistry Schizophrenia Chronic schizophrenia Female Neurology (clinical) business medicine.drug Antipsychotic Agents |
| Zdroj: | European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 6(2) |
| ISSN: | 0924-977X |
| Popis: | The relationship between chlorpromazine, six of its metabolites and therapeutic response in chronic schizophrenic patients was investigated in this study. Logistic regression revealed no correlation between therapeutic response and four metabolites viz. Nor1 chlorpromazine, Nor2 chlorpromazine, chlorpromazine-N-oxide and Nor2 chlorpromazine sulfoxide. A good correlation was seen between CPZ (P = 0.036), 7-hydroxychlorpromazine (P = 0.004), chlorpromazine sulfoxide (P = 0.002) and therapeutic response. Good therapeutic response was correlated to high levels of chlorpromazine and its 7-hydroxy metabolite while high levels of the sulfoxide metabolite appeared to have a negative effect on therapeutic response. Poor responders who had high levels of chlorpromazine also had high levels of the sulfoxide metabolite. This suggests that the difference in response may lie in the difference in the metabolism of the drug. |
| Databáze: | OpenAIRE |
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