Genetic and epigenetic alterations on the short arm of chromosome 11 are involved in a majority of sporadic Wilms' tumours
| Autor: | Yasuhiko Kaneko, T Nakagawachi, Jiro Uozumi, Z Masaki, Ken Higashimoto, Tsunehiro Mukai, Y. Satoh, Keiichiro Joh, Hidenobu Soejima, Hisaya Nakadate |
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| Rok vydání: | 2006 |
| Předmět: |
Cancer Research
Genes Wilms Tumor loss of imprinting Loss of Heterozygosity Locus (genetics) Biology Wilms Tumor Epigenesis Genetic Loss of heterozygosity Insulin-Like Growth Factor II medicine Humans genetics Epigenetics Wilms' tumour Cyclin-Dependent Kinase Inhibitor p57 Gene beta Catenin Genetics DNA methylation epigenetics Chromosomes Human Pair 11 Proteins Chromosome Genetics and Genomics Wilms' tumor medicine.disease Kidney Neoplasms Oncology Child Preschool Mutation Cancer research Genomic imprinting |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| Popis: | Wilms' tumour is one of the most common solid tumours of childhood. 11p13 (WT1 locus) and 11p15.5 (WT2 locus) are known to have genetic or epigenetic aberrations in these tumours. In Wilms' tumours, mutation of the Wilms tumour 1 (WT1) gene at the WT1 locus has been reported, and the WT2 locus, comprising the two independent imprinted domains IGF2/H19 and KIP2/LIT1, can undergo maternal deletion or alterations associated with imprinting. Although these alterations have been identified in many studies, it is still not clear how frequently combined genetic and epigenetic alterations of these loci are involved in Wilms' tumours or how these alterations occur. To answer both questions, we performed genetic and epigenetic analyses of these loci, together with an additional gene, CTNNB1, in 35 sporadic Wilms' tumours. Loss of heterozygosity of 11p15.5 and loss of imprinting of IGF2 were the most frequent genetic (29%) and epigenetic (40%) alterations in Wilms' tumours, respectively. In total, 83% of the tumours had at least one alteration at 11p15.5 and/or 11p13. One-third of the tumours had alterations at multiple loci. Our results suggest that chromosome 11p is not only genetically but also epigenetically critical for the majority of Wilms' tumours. |
| Databáze: | OpenAIRE |
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