Survival analysis of oropharyngeal squamous cell carcinoma patients linked to histopathology, disease stage, tumor stage, risk factors, and received therapy
| Autor: | Andrejs Lifsics, E Rate, Valērija Groma, A Ivanova, Juris Tars, Modra Murovska |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Oncology
Adult Male Cancer Research medicine.medical_specialty Alcohol Drinking medicine.medical_treatment Disease Kaplan-Meier Estimate 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine medicine Humans Oropharyngeal squamous cell carcinoma Stage (cooking) Survival analysis Aged Neoplasm Staging Retrospective Studies Aged 80 and over Soft palate Proportional hazards model business.industry Smoking Age Factors Middle Aged Progression-Free Survival Radiation therapy Oropharyngeal Neoplasms medicine.anatomical_structure 030220 oncology & carcinogenesis Carcinoma Squamous Cell Histopathology Female business |
| Zdroj: | Experimental oncology. 42(1) |
| ISSN: | 1812-9269 |
| Popis: | Background Survival of oropharyngeal squamous cell carcinoma (OSCC) patients depends on the risk and environmental factors, tumor biology, achievements in diagnostics and treatment approaches. Aim To perform a survival analysis of the patients with OSCC treated over a 10-year period in a single hospital in Latvia linking these data to histopathological findings, risk factors and received therapy. Materials and methods The main outcome measures were overall and disease-specific survival (OS and DS) along with histopathology analysis. Results Kaplan - Meier survival analysis showed better survival for females, younger patients lacking bad habits, operated and received radiotherapy, with lower T grade and disease stage. Cox regression showed diminished early death risk in patients with lower T grade, no regional metastases (N0) and bad habits, operated and received radiotherapy. A vast majority of tumors were localized in palatine tonsils and the base of the tongue. The localization did not correlate with mean survival time/survival. Lower OS (p = 0.03) and DS (p = 0.026) were estimated for patients with pharyngeal wall and tonsillar involvement compared to tumors localized in the soft palate. A histological variant of tumor seemed irrelevant estimating OS and DS, whereas therapeutic modalities significantly affected survival. Conclusions OSCC patients with lower T grade, N0 status, lacking bad habits, and surgically treated had better survival. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|