Early-life famine exposure and rheumatoid arthritis in Chinese adult populations: a retrospective cohort study
| Autor: | Fan Yang, Hao Zhang, Kun Tang, Chunyu Liu, Xiangrui Meng, Xiaoyu Pan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male 0301 basic medicine China medicine.medical_specialty Population Logistic regression Metabolic equivalent Arthritis Rheumatoid Cohort Studies 03 medical and health sciences 0302 clinical medicine Pregnancy Epidemiology Prevalence medicine Humans 030212 general & internal medicine education Retrospective Studies nutrition & dietetics education.field_of_study Famine business.industry Infant Retrospective cohort study General Medicine medicine.disease bone diseases 030104 developmental biology Child Preschool Prenatal Exposure Delayed Effects Rheumatoid arthritis Medicine Female epidemiology Public Health business Body mass index Demography |
| Zdroj: | BMJ Open, Vol 11, Iss 7 (2021) BMJ Open |
| ISSN: | 2044-6055 |
| Popis: | ObjectiveThis study aimed to explore the association between famine exposure in early life and the odds of rheumatoid arthritis (RA) in adulthood.DesignA population-based retrospective cohort study.SettingChina.ParticipantsA total of 111 706 participants (1775 with RA) born from 1956 to 1964 were selected from the baseline survey of a large cohort in China.Primary and secondary outcome measuresFour famine exposure groups were generated based on dates of birth, namely prenatal-exposed, infant-exposed, preschool-exposed and non-exposed groups. Logistic regressions were used to explore the association between famine exposure and self-reported RA in adulthood, adjusting for sex, region, monthly income, highest education, alcohol consumption, tobacco use, body mass index (BMI) and metabolic equivalent tasks. Analyses were also performed with stratification for sex (female or male), residing region (urban or rural), famine severity (severe or non-severe) and BMI (≥24 or ResultsThe study included 1775 (1.59%) RA cases and 109 931 (98.41%) non-RA controls. Among them, 22 413 (20.06%) were prenatal-exposed, 14 899 (13.34%) were infant-exposed and 34 356 (30.76%) were preschool-exposed. Prenatal exposure to famine was not associated with onset of RA in adulthood. Infant-exposed group and preschool-exposed group had significantly elevated odds of getting RA compared with non-exposed group (infant-exposed: OR=1.44, 95% CI 1.24 to 1.67; preschool-exposed: OR=1.38, 95% CI 1.22 to 1.57, pConclusionsExposure to the Great Chinese Famine in early life after birth especially in infancy may be associated with a higher risk of RA in adulthood. Strengthening early-life nutrition could be an implication to prevent future RA. |
| Databáze: | OpenAIRE |
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