Drug dispersion degree and drug dissolution rate in Hybrane S1200-based instant-release matricial particles prepared by hot melt extrusion
| Autor: | José Luis Gómez-Amoza, Elena Raviña-Eirín, Ramón Martínez-Pacheco |
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| Rok vydání: | 2014 |
| Předmět: |
Hot Temperature
Materials science Chemistry Pharmaceutical Drug Compounding Polyesters Prednisolone Pharmaceutical Science Die swell Differential scanning calorimetry X-Ray Diffraction Drug Discovery Dissolution testing Particle Size Dissolution Pharmacology Drug Carriers Chromatography Calorimetry Differential Scanning Organic Chemistry Water Drug Liberation Solubility Chemical engineering Microscopy Electron Scanning Extrusion Particle size Crystallization Dispersion (chemistry) Drug carrier |
| Zdroj: | Drug Development and Industrial Pharmacy. 41:1000-1005 |
| ISSN: | 1520-5762 0363-9045 |
| DOI: | 10.3109/03639045.2014.922572 |
| Popis: | The objective of this study is to evaluate the dissolution of a poorly soluble drug (prednisolone) from different sized matricial particles (from250 to1500 µm) with two drug contents (10% or 20%) obtained by hot melt extrusion using the hyperbranched polyesteramide Hybrane S1200 (water-soluble and with a Tg of 45 °C) as the carrier. X-ray diffraction, differential scanning calorimetry and SEM studies permit us to conclude that in 10% prednisolone extrudate, the drug is mainly dispersed within the carrier, whereas in those containing 20% an important fraction of the drug remains in a crystalline state and is accumulated on the surface of the extrudates. On particles proceeding from 10% drug extrudate, the drug dissolution rate is very high and slightly dependant on particle size and in all cases, higher than the pure micronized drug. However, on particles proceeding from 20% prednisolone extrudate particle size have a major effect on drug dissolution rate, attributable to higher proportions of crystalline drug accumulated on the surface, hindering polymer dissolution. Thus, the reduction of the particle size after extrudate grinding creates new surfaces from inside, that leads to strong increments on prednisolone dissolution rate, and becomes higher than the pure micronized drug one when the particle size is250 µm. |
| Databáze: | OpenAIRE |
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