Human Is a Unique Species among Primates in Terms of Telomere Length
| Autor: | Shingo Kakuo, Kazuo Asaoka, Toshinori Ide |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Male
Aging Telomerase Pan troglodytes Hominidae Biophysics Biochemistry Restriction fragment Pongo pygmaeus biology.animal Animals Humans Tissue Distribution Primate Molecular Biology Cellular Senescence Genetics biology DNA Restriction Enzymes Cell Biology Telomere biology.organism_classification biology.protein Macaca Common chimpanzee Female Cell aging |
| Zdroj: | Biochemical and Biophysical Research Communications. 263:308-314 |
| ISSN: | 0006-291X |
| Popis: | TRF (terminal restriction fragments) length in various tissues of non-human primates such as Macaca mulatta (rhesus monkey), Macaca fuscata (Japanese monkey), Macaca fascicularis (crab-eating monkey), Pan troglodytes (common chimpanzee), and Pongo pygmaeus (orangutan) was at least 23 kb without exception, which was quite different from that of human somatic tissues (smaller than 10 kb). The distribution pattern of telomerase activity among tissues was similar between human and non-human primates, while the activity level showed some differences such as that strong telomerase activity was observed in gastrointestinal and lymphocytic tissues from non-human primates. The human appears to be a unique species among primates in terms of telomere length. |
| Databáze: | OpenAIRE |
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