Variation of glycinamide ribonucleotide synthetase levels during in vitro aging of human fibroblasts: Implications for gene dosage studies

Autor:	Robert G. Hards, David Patterson
Rok vydání:	1986
Předmět:	Senescence Aging biology Trisomy Fibroblasts medicine.disease Diploidy Gene dosage Molecular biology Enzyme assay Cell Line Ligases Kinetics medicine.anatomical_structure Cell culture medicine biology.protein Humans Carbon-Nitrogen Ligases Ploidy Chromosome 21 Fibroblast Developmental Biology
Zdroj:	Mechanisms of Ageing and Development. 36:65-70
ISSN:	0047-6374
DOI:	10.1016/0047-6374(86)90139-9
Popis:	The levels of glycinamide ribonucleotide synthetase were monitored in four human fibroblast cell lines, two diploid, one monosomy 21 and one trisomy 21, from early passage number to senescence. In all four lines, enzyme activity increased as the cells aged. Enzyme levels for the diploid versus trisomy 21 cells did not consistently exhibit the expected gene dosage effect.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a61dec1b7f2c32b6f1de46207ddbfd74 https://doi.org/10.1016/0047-6374(86)90139-9 Zobrazit plný text záznamu