All-cause and cause-specific mortality following non-traumatic spinal cord injury: evidence from a population-based cohort study in Switzerland
| Autor: | Marcel Zwahlen, Martin W. G. Brinkhof, Martin Schubert, Jonviea D Chamberlain, Xavier Jordan, Anne Buzzell, Inge Eriks-Hoogland, Kerstin Hug |
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| Přispěvatelé: | University of Zurich, Brinkhof, M W G |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Epidemiology Population 610 Medicine & health Comorbidity Disease Infections Article Young Adult 03 medical and health sciences 0302 clinical medicine 360 Social problems & social services Cause of Death Neoplasms Internal medicine Humans Medicine Longitudinal Studies 030212 general & internal medicine education Spinal Cord Injuries Aged Cause of death education.field_of_study business.industry Mortality rate Medical record General Medicine Middle Aged medicine.disease 3. Good health 2728 Neurology (clinical) Risk factors Neurology Cardiovascular Diseases 2808 Neurology Etiology Female 10046 Balgrist University Hospital Swiss Spinal Cord Injury Center Neurology (clinical) business Switzerland 030217 neurology & neurosurgery Cohort study |
| Zdroj: | Spinal Cord Buzzell, A; Chamberlain, J D; Eriks-Hoogland, I; Hug, K; Jordan, X; Schubert, M; Zwahlen, M.; Brinkhof, M W G (2020). All-cause and cause-specific mortality following non-traumatic spinal cord injury: evidence from a population-based cohort study in Switzerland. Spinal cord, 58(2), pp. 157-164. Nature Publishing Group 10.1038/s41393-019-0361-6 |
| ISSN: | 1476-5624 1362-4393 |
| DOI: | 10.1038/s41393-019-0361-6 |
| Popis: | Study designObservational cohort study.ObjectiveTo benchmark all-cause and cause-specific mortality following NTSCI to the general population (GP).SettingSpecialized rehabilitation centers in Switzerland.MethodsLongitudinal data from the Swiss Spinal Cord Injury (SwiSCI) Medical Record study were probabilistically linked with cause of death (CoD) information from the Swiss National Cohort. Standardized mortality ratios (SMRs) were estimated for all-cause and cause-specific mortality. Competing risk frameworks were used to estimate the probability of death due to specific CoD.ResultsOne thousand five hundred and one individuals were admitted for first rehabilitation with NTSCI between 1990–2011; CoD information was available for 454 individuals of the 525 individuals that died. Overall, the mortality rate for persons with NTSCI was 1.6 times greater than that of the GP. Deaths due to cardiovascular disease (39.8%), neoplasms (22%), and infection (9.9%) were most often reported. Individuals with an SCI due to a vascular etiology indicated the greatest burden of mortality from infection compared with the GP (SMR 5.4; 95% CI, 3.1 to 9.2).ConclusionsCause-specific SMRs varied according to etiology. This supports the need for targeted clinical care and follow-up. Cardiovascular disease, neoplasms, and infection, emerged as main causes of death following NTSCI and should thus be targets for future research and differential clinical management approaches. |
| Databáze: | OpenAIRE |
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