Plasma Extracellular Superoxide Dismutase Activity in Healthy Pregnant Women Is Not Influenced by Zinc Supplementation
| Autor: | Kelley E. Johnston, Tsunenobu Tamura, Mary B. DuBard, Carl L. Keen, Katherine L. Olin, Robert L. Goldenberg |
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| Rok vydání: | 2001 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism Clinical Biochemistry Population chemistry.chemical_element Zinc Placebo Biochemistry Inorganic Chemistry Double-Blind Method Pregnancy Internal medicine medicine Humans Micronutrients education education.field_of_study Superoxide Dismutase Chemistry Biochemistry (medical) Nutritional Requirements Pregnancy Outcome General Medicine Alkaline Phosphatase medicine.disease Endocrinology Extracellular superoxide dismutase Zinc deficiency Alkaline phosphatase Gestation Female Extracellular Space Copper |
| Zdroj: | Biological Trace Element Research. 80:107-113 |
| ISSN: | 0163-4984 |
| Popis: | We hypothesized that plasma extracellular superoxide dismutase (EC-SOD) activity reflects the zinc nutriture of healthy pregnant women. Sixty-three women were selected from 580 African-American women who participated in a clinical trial to evaluate the effect of prenatal zinc supplementation on pregnancy outcome. Half of the women received zinc (25 mg/d) and the other half was given a placebo from about 19 wk gestation to delivery. In the trial, a positive effect of zinc supplementation on birthweight was observed, indicating that the population as a whole had suboptimal zinc nutriture. Using plasma samples obtained during the trial, EC-SOD activities were measured and the values were compared with plasma zinc concentrations and plasma alkaline phosphatase activities. Plasma EC-SOD activities in our subjects were lower than previously published values for healthy adults in Korea. Although plasma EC-SOD activity may reflect severe zinc deficiency, it is not a sensitive marker for marginal deficiency status. Plasma EC-SOD activities did not prove to be a better indicator of zinc nutriture of pregnant women than either plasma zinc or plasma alkaline phosphatase activities. |
| Databáze: | OpenAIRE |
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