The Interplay Between C-Myc Oncogene Expression and Circulating Vascular Endothelial Growth Factor (sVEGF), Its Antagonist Receptor, Soluble Flt-1 in Diffuse Large B Cell Lymphoma (DLBCL): Relationship to Patient Outcome
| Autor: | M. Sakrana, K Zalata, Salah Aref, Mohamed Mabed, H El Askalany |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Vascular Endothelial Growth Factor A Cancer Research Pathology medicine.medical_specialty Lymphoma B-Cell Angiogenesis Biology Severity of Illness Index Proto-Oncogene Proteins c-myc chemistry.chemical_compound medicine Humans Aged Extracellular Matrix Proteins Vascular Endothelial Growth Factor Receptor-1 Oncogene Beta-2 microglobulin Case-control study Hematology Middle Aged Prognosis medicine.disease Vascular endothelial growth factor Vascular endothelial growth factor A Treatment Outcome Oncology chemistry Case-Control Studies Multivariate Analysis Cancer research Immunohistochemistry Angiogenesis Inducing Agents Female Lymph Nodes Lymphoma Large B-Cell Diffuse beta 2-Microglobulin Diffuse large B-cell lymphoma |
| Zdroj: | Leukemia & Lymphoma. 45:499-506 |
| ISSN: | 1029-2403 1042-8194 |
| DOI: | 10.1080/10428190310001607151 |
| Popis: | The c-Myc is a ubiquitous and multifunctional oncogene. Recently, data obtained from experimental study suggests the involvement of c-Myc oncogene in angiogenesis. In the present study the interrelation of sVEGF, sFlt-1 concentrations and c-Myc oncoprotein expression at diagnosis were assessed in DLBCL and their impact on the patient outcome. Forty-five DLBCL patients beside 10 normal controls were included. C-Myc oncoprotein was assessed by immunohistochemistry. SVEGF and sFlt-1 were determined by enzyme linked immunosorbent assay. C-Myc over-expression was detected in 66.6% of DLBCL. The DLBCL patient group with positive c-Myc over-expression showed significantly higher sVEGF and significantly decreased sFlt-1 as compared to group with negative c-Myc over-expression (P = 0.000 and P = 0.009 respectively). SVEGF was positively correlated to sLDH and s.beta2 microglobulin (r = 0.6, P = 0.000, r = 0.69, P = 0.000) respectively. On the other hand sFlt-1 was negatively correlated to sLDH and s.beta2 microglobulin (r - 0.25, P0.05, r - 0.49, P = 0.001) respectively. The non-living DLBCL group showed significantly higher expression of c-Myc, higher concentration of sVEGF and lower concentration in sFlt-1 level as compared to the living group (P = 0.000 for all). Multivariate analysis revealed that c-Myc over-expression; high sVEGF and normal sFlt-1 levels at diagnosis had independent adverse influence on survival (relative risk: 17.9, 35.7, 29.3, 2.63; P0.0001, P0.0001, and P = 0.03 respectively)C-Myc over-expression significantly associated with high sVEGF and normal sFlt-1 level in DLBCL patients, suggesting a complex interrelationship between c-Myc oncogene expression and angiogenic regulators. C-Myc over-expression, high sVEGF and normal sFLt-1 levels at diagnosis had an independent adverse influence on survival in DLBCL patients and considered bad prognostic markers. |
| Databáze: | OpenAIRE |
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