Managing regional metastasis in patients with cutaneous head and neck melanoma – is selective neck dissection appropriate?
| Autor: | Mrinal Supriya, Vignesh Narasimhan, Michael A. Henderson, Andrew Sizeland |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Skin Neoplasms medicine.medical_treatment Metastasis Humans Medicine Progression-free survival Head and neck Melanoma Pathological Retrospective Studies business.industry Neck dissection Middle Aged medicine.disease Surgery Survival Rate Radiation therapy Treatment Outcome Otorhinolaryngology Head and Neck Neoplasms Lymphatic Metastasis Cutaneous melanoma Lymph Node Excision Neck Dissection Female Radiotherapy Adjuvant Neoplasm Recurrence Local business |
| Zdroj: | American Journal of Otolaryngology. 35:610-616 |
| ISSN: | 0196-0709 |
| DOI: | 10.1016/j.amjoto.2014.06.011 |
| Popis: | Background Neck dissection is recommended for patients with head and neck cutaneous melanoma and nodal metastasis. However, there appears to be no clear evidence to guide the extent of nodal resection. Methods Loco-regional recurrence (LR), overall survival (OS) and progression free survival (PFS) was retrospectively compared between patients who had Comprehensive neck dissection (CND) and Selective neck dissection (SND). Results There was no difference in LR, OS and PFS between CND (n = 18) and SND groups (n = 79). Extra capsular extension (ECE), frontal disease and increasing number of involved nodes resulted in worse OS and PFS but had no impact on LR. Conclusion Patients with disease limited to one node without ECE can be effectively treated by SND alone. In patients who have these unfavourable pathological features more extensive nodal resection does not improve outcome if they receive radiotherapy. Extent of neck dissection or adjuvant radiotherapy has no impact on overall survival. |
| Databáze: | OpenAIRE |
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