The cutoff values of serum AMH levels and starting recFSH doses for the individualization of IVF treatment strategies

Autor: Oya Akcin, Çiğdem Kaspar, Meltem Güner Can, Cem Ficicioglu, Pinar Ozcan, Mert Yesiladali, Seda Ates
Přispěvatelé: ÖZCAN, PINAR, Özcan, P., Fiçicioğlu, C., Ateş, S., Can, M.G., Kaspar, Ç., Akçin, O., Yesiladali, M., Yeditepe Üniversitesi
Rok vydání: 2017
Předmět:
Adult
Anti-Mullerian Hormone
endocrine system
Pregnancy Rate
endocrine system diseases
medicine.drug_class
Endocrinology
Diabetes and Metabolism
Physiology
Prospective data
030209 endocrinology & metabolism
Fertilization in Vitro
Biology
ÖZCAN P.
Ficicioglu C.
ATEŞ S.
GÜNER CAN M.
Kaspar C.
Akcin O.
Yesiladali M.
-The cutoff values of serum AMH levels and starting recFSH doses for the individualization of IVF treatment strategies-
GYNECOLOGICAL ENDOCRINOLOGY
cilt.33
ss.467-471
2017
Andrology
03 medical and health sciences
0302 clinical medicine
Endocrinology
Ovulation Induction
Pregnancy
AMH
medicine
Humans
Cutoff
Precision Medicine
Ovarian Reserve
ovarian response
Ivf treatment
030219 obstetrics & reproductive medicine
urogenital system
Obstetrics and Gynecology
poor response
assisted reproduction technology
ovarian stimulation
female genital diseases and pregnancy complications
IVF
Female
Follicle Stimulating Hormone
Gonadotropin
hormones
hormone substitutes
and hormone antagonists
Hormone
Zdroj: Gynecological Endocrinology. 33:467-471
ISSN: 1473-0766
0951-3590
DOI: 10.1080/09513590.2017.1294154
Popis: Objective: The main purpose of our study is to categorize starting doses of recombinant follicle-stimulating hormone (recFSH) based on various cutoff values of anti-Mullerian hormone (AMH) and to determine the effectiveness of serum AMH levels in the prediction of poor ovarian response. Material and methods: Prospective data analysis was conducted at IVF center. A total of 323 patients were included. All patients were divided into four groups according to the patients’ serum AMH concentrations: Group 1 (AMH < 1 ng/ml; 450 IU/day n = 157); Group 2 (AMH 1–2 ng/ml; 375 IU/day, n = 55); Group 3 (AMH 2–3 ng/ml; 225 IU/day, n = 48); and Group 4 (AMH > 3 ng/ml; 150 IU/day, n = 63). Collected data included age, total gonadotropin dosage, duration of stimulations, the total number of oocytes retrieved, ovarian response, cancelation rate, and cPRs. Results: As serum AMH levels increased, there were significant decreases in the starting recFSH dose and total gonadotropin dosage, and a significant increase in the total number of oocytes retrieved. There was a significant trend toward increasing cycle cancelation rates and decreasing cPRs with decreasing serum AMH levels. Although there were no significant differences with regard to the proportion of cycles with hypo-response between all groups. A result of ?0.83 was considered the cutoff value of AMH to predict a hypo-response to ovarian stimulation. Conclusions: AMH is a useful marker in selecting the starting dose of recFSH and prediction of poor ovarian response. Our protocol may allow clinicians to modulate the starting dose of recFSH according to these cutoff values for serum AMH levels. © 2017 Informa UK Limited, trading as Taylor & Francis Group.
Databáze: OpenAIRE
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