Front microrheology of the non-Newtonian behaviour of blood: Scaling theory of erythrocyte aggregation by aging
| Autor: | Ivon Rodriguez-Villarreal, Claudia Trejo-Soto, Mario Castro, Aurora Hernández-Machado, E. Costa-Miracle, Joan Cid, Tomás Alarcón |
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| Přispěvatelé: | Universitat de Barcelona |
| Rok vydání: | 2017 |
| Předmět: |
Microrheology
02 engineering and technology Blood plasma 01 natural sciences Quantitative Biology::Cell Behavior Physics::Fluid Dynamics Viscosity Rheology 0103 physical sciences Statistical physics 010306 general physics Scaling 51 - Matemàtiques Microscale chemistry Chemistry Plasma sanguini General Chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics Capillary number Non-Newtonian fluid Shear rate Viscositat Rheology (Biology) Matemàtiques 0210 nano-technology Reologia (Biologia) |
| Zdroj: | RECERCAT (Dipòsit de la Recerca de Catalunya) Recercat. Dipósit de la Recerca de Catalunya instname Dipòsit Digital de la UB Universidad de Barcelona Recercat: Dipósit de la Recerca de Catalunya Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Popis: | We introduce a new framework to study the non-Newtonian behaviour of fluids at the microscale based on the analysis of front advancement. We apply this methodology to study the non-linear rheology of blood in microchannels. We carry out experiments in which the non-linear viscosity of blood samples is quantified at different haematocrits and ages. Under these conditions, blood exhibits a power-law dependence on the shear rate. In order to analyse our experimental data, we put forward a scaling theory which allows us to define an adhesion scaling number. This theory yields a scaling behaviour of the viscosity expressed as a function of the adhesion capillary number. By applying this scaling theory to samples of different ages, we are able to quantify how the characteristic adhesion energy varies as time progresses. This connection between microscopic and mesoscopic properties allows us to estimate quantitatively the change in the cell–cell adhesion energies as the sample ages. |
| Databáze: | OpenAIRE |
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