Modifiable Risk Factors and Brain Positron Emission Tomography Measures of Amyloid and Tau in Nondemented Adults with Memory Complaints
| Autor: | Florangel Rueda, David A. Merrill, Prabha Siddarth, Susan Y. Bookheimer, Jorge R. Barrio, Natacha D. Emerson, Helen Lavretsky, Alison C. Burggren, Gary W. Small, Cyrus A. Raji, Karen J. Miller, Laurel M. Harris, Linda M. Ercoli |
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| Rok vydání: | 2016 |
| Předmět: |
Gerontology
Male Aging Self-Assessment Plaque Amyloid Mediterranean Neurodegenerative Diet Mediterranean Alzheimer's Disease Gastroenterology Normal body weight 0302 clinical medicine Risk Factors 2.1 Biological and endogenous factors Aetiology Plaque Brain Neurofibrillary Tangles Middle Aged Psychiatry and Mental health Neurological Public Health and Health Services Biomedical Imaging Female Cognitive Sciences Alzheimer's disease Alzheimer disease social and economic factors Psychology medicine.medical_specialty Amyloid 1.1 Normal biological development and functioning Clinical Sciences Article 03 medical and health sciences Alzheimer Disease Underpinning research Clinical Research 2.3 Psychological Internal medicine Behavioral and Social Science medicine Brain positron emission tomography Acquired Cognitive Impairment Humans Cognitive Dysfunction Exercise physiology Exercise Aged Nutrition Memory Disorders 030214 geriatrics Prevention Neurosciences Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) Protective Factors medicine.disease Healthy diet Diet Brain Disorders PET Geriatrics Posterior cingulate Positron-Emission Tomography FDDNP Dementia Geriatrics and Gerontology Body mass index 030217 neurology & neurosurgery |
| Zdroj: | The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, vol 24, iss 9 Merrill, DA; Siddarth, P; Raji, CA; Emerson, ND; Rueda, F; Ercoli, LM; et al.(2016). Modifiable Risk Factors and Brain Positron Emission Tomography Measures of Amyloid and Tau in Nondemented Adults with Memory Complaints. AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY, 24(9), 729-737. doi: 10.1016/j.jagp.2016.05.007. UCLA: Retrieved from: http://www.escholarship.org/uc/item/7b09f9jd |
| Popis: | Objective Exercise and diet impact body composition, but their age-related brain effects are unclear at the molecular imaging level. To address these issues, the authors determined whether body mass index (BMI), physical activity, and diet relate to brain positron emission tomography (PET) of amyloid plaques and tau tangles using 2-(1-(6-[(2-[F-18]fluoroethyl)(methyl)amino]-2-naphthyl)ethylidene)malononitrile (FDDNP). Methods Volunteers (N = 44; mean age: 62.6 ± 10.7 years) with subjective memory impairment (N = 24) or mild cognitive impairment (MCI; N = 20) were recruited by soliciting for memory complaints. Levels of physical activity and extent of following a Mediterranean-type diet were self-reported. FDDNP-PET scans assessed plaque/tangle binding in Alzheimer disease–associated regions (frontal, parietal, medial and lateral temporal, posterior cingulate). Mixed models controlling for known covariates examined BMI, physical activity, and diet in relation to FDDNP-PET. Results MCI subjects with above normal BMI (>25) had higher FDDNP-PET binding compared with those with normal BMI (1.11(0.03) versus 1.08(0.03), ES = 1.04, t(35) = 3.3, p = 0.002). Greater physical activity was associated with lower FDDNP-PET binding in MCI subjects (1.07(0.03) versus 1.11(0.03), ES = 1.13, t(35) = −3.1, p = 0.004) but not in subjects with subjective memory impairment (1.07(0.03) versus 1.07(0.03), ES = 0.02, t(35) = −0.1, p = 0.9). Healthier diet related to lower FDDNP-PET binding, regardless of cognitive status (1.07(0.03) versus 1.09(0.02), ES = 0.72, t(35) = −2.1, p = 0.04). Conclusion These preliminary findings are consistent with a relationship between risk modifiersand brain plaque/tangle deposition in nondemented individuals and supports maintenance of normal body weight, regular physical activity, and healthy diet to protect the brain during aging. (clinicaltrials.gov; NCT00355498). |
| Databáze: | OpenAIRE |
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