Protective Effect of Reamberin on Functional Activity of Mitochondria during Skin Ischemia
| Autor: | N. V. Lapina, A. V. Agadzhanova, T. M. Berberashvili, V. P. Galenko-Yaroshevskii, A. S. Gorelashvili, K. O. Fedorovich, G. V. Sukoyan |
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| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Necrosis Phosphocreatine Aspartate transaminase Reductase Creatine Antioxidants General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Adenosine Triphosphate Ischemia Internal medicine Lactate dehydrogenase medicine Animals Aspartate Aminotransferases Creatine Kinase Skin chemistry.chemical_classification L-Lactate Dehydrogenase biology Superoxide Dismutase Electron Transport Complex II Glutathione peroxidase Succinate dehydrogenase Rats Inbred Strains Succinates General Medicine Mitochondria Rats Endocrinology chemistry Biochemistry biology.protein Creatine kinase medicine.symptom |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 140:435-438 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-005-0513-x |
| Popis: | Reamberin in a dose of 25 mg/kg (succinate concentration) was injected intravenously for 3 days starting from the 1st hour after skin ischemia modeling. This treatment decreased activities of lactate dehydrogenase, aspartate transaminase, and creatine phosphokinase in skin homogenates by 1.6 times, 19%, and 51.3%, respectively. The index of cytolysis decreased by 18%. Reamberin had an energotropic effect, which manifested in an increase in the total ATP content and concentration of creatine phosphate (by 16 and 10%, respectively). After administration of Reamberin, activity of the succinate-ubiquinone reductase system increased by 17%. Under these conditions succinate dehydrogenase activity exceeded the normal by 21%. Reamberin had no effect on the mitochondrial NADH-ubiquinone reductase system in dermal cells during skin ischemia. Superoxide dismutase activity in the area of necrosis increased to the control level on day 3 of treatment with Reamberin. Activities of catalase and glutathione peroxidase increased by 13 and 19%, respectively. Our results indicate that the course of intravenous treatment with Reamberin for 3 days contributes to an increase in reserve capacities of the antioxidant protection system and produces a protective effect during skin ischemia. |
| Databáze: | OpenAIRE |
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